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51543-40-9 ((R)-Flurbiprofen)

1

Identification

(R)-Flurbiprofen (R)-Flurbiprofen
Name (R)-Flurbiprofen
Formula C15H13FO2
MW 244.2609
CAS No. 51543-40-9
EINECS 257-264-7
Smiles O=C(O)[[email protected]](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
Synonyms E7869;Tarenflurbil;MPC7869
InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
2

Introduction

(R)-Flurbiprofen is the R-enantiomer of the racemate NSAID Flurbiprofen, (R)-Flurbiprofen inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM.

Background Information

Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
......by AdooQ BioScience, LLC
(S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. ......by AdooQ BioScience, LLC
(R)-Flurbiprofen is the R-isomer of Flurbiprofen. ......by BOC Sciences
(R)-Flurbiprofen is the R-enantiomer of the racemate NSAID Flurbiprofen, (R)-Flurbiprofen inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. ......by MedChemexpress Co., Ltd.
Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation. ......by MedKoo Biosciences, Inc.
A non-steroidal anti-inflammatory drug (NSAID); primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain; cyclooxygenase (COX) inhibitor.PainApproved ......by ProbeChem
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000024417

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
(R)-Flurbiprofen National Institute of Dental and Craniofacial Research (NIDCR) Pain 1999/11/3 2001/11/1 Phase 2 Clinical
(R)-Flurbiprofen Reckitt Benckiser LLC Pharyngitis 2010/1/13 2011/4/1 Phase 3 Clinical
(R)-Flurbiprofen Reckitt Benckiser LLC Acute Pharyngitis Sore Throat 2013/10/22 2013/11/1 Phase 3 Clinical
(R)-Flurbiprofen - Phase 2
7

Safety Data of (R)-Flurbiprofen

Hazard Symbols : T
Risk Statements : R25
Safety Statements : S26;S36/37/39;S45
Transport Information : UN 2811
WGKGermany : 3
8

Spectral Information

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Suppliers List

10

Related Products

Other Forms of 51543-40-9

Name CAS No Formula MW

Recommended Compounds in RAR/RXR

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 196996 958295-17-5 C24H20BrNO5 482.32
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Acitretin 55079-83-9 C21H26O3 326.43
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Magnolol 528-43-8 C18H18O2 266.33
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Isotretinoin 4759-48-2 C20H28O2 300.44
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
Tamibarotene 94497-51-5 C22H25NO3 351.44
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
Tropisetron 89565-68-4 C17H20N2O2 284.35
Capsaicin 404-86-4 C18H27NO3 305.41
Etodolac 41340-25-4 C17H21NO3 287.35
Sufentanil 56030-54-7 C22H30N2O2S 386.55
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
Cebranopadol 863513-91-1 C24H27FN2O 378.48
Gabapentin (hydrochloride) 60142-95-2 C9H18ClNO2 207.7
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Gabapentin 60142-96-3 C9H17NO2 171.24
Sufentanil (citrate) 60561-17-3 C28H38N2O9S 578.67
Nepafenac 78281-72-8 C15H14N2O2 254.28
Celecoxib 169590-42-5 C17H14F3N3O2S 381.37
Atomoxetine (hydrochloride) 82248-59-7 C17H22ClNO 291.82
Diazepam 439-14-5 C16H13ClN2O 284.74
Naloxone (hydrochloride) 357-08-4 C19H22ClNO4 363.84
Etoricoxib 202409-33-4 C18H15ClN2O2S 358.84
Pregabalin 148553-50-8 C8H17NO2 159.23
Rofecoxib 162011-90-7 C17H14O4S 314.36
Tapentadol (hydrochloride) 175591-09-0 C14H24ClNO 257.8
(S)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole 1252673-29-2 C22H26N2O2S 382.519
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Route of Synthesis

12

References

13

More Information

(R)-Flurbiprofen

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