• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

154235-83-3 (Ampalex)

1

Identification

Ampalex Ampalex
Name Ampalex
Formula C14H15N3O
MW 241.29
CAS No. 154235-83-3
EINECS
Smiles O=C(N1CCCCC1)C2=CC(N=CC=N3)=C3C=C2
Synonyms 1-(Quinoxalin-6-ylcarbonyl)piperidine; Piperidin-1-yl-quinoxalin-6-ylmethanone; piperidin-1-yl(quinoxalin-6-yl)methanone
InChI InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
2

Introduction

Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

Background Information

AMPA modulator for the potential treatment of Alzheimer's disease and mild cognitive impairment (MCI) ......by AOBIOUS INC
CX516 is a positive allosteric modulator at AMPA receptor that inhibits the deactivation of AMPA receptors. CX-516 is a nootropic and ampakine agent. ......by BOC Sciences
Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light brown to brown solid EBNumber:EB000023924

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ampalex North Suffolk Mental Health Association Schizophrenia 2002/2/28 2005/4/30 Phase 3 Clinical
Ampalex Cortex Pharmaceuticals Inc Autism 2002/6/30 Phase 2 Clinical
Ampalex Cortex Pharmaceuticals Inc Fragile X syndrome 2002/6/30 Phase 2 Clinical
Ampalex Cortex Pharmaceuticals Inc Mild cognitive impairment 2002/4/30 2003/3/31 Phase 2 Clinical
Ampalex National Institute of Neurological Disorders and Stroke Alzheimers disease 1996/12/1 2005/11/1 Phase 2 Clinical
Ampalex - Discontinued
Ampalex - Phase 3
7

Safety Data of Ampalex

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD13() USA
Alfa Chemistry USA
Apichem Chemical Technology Co., Ltd. China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD60();50mg/USD120() USA
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD120() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD120() China
Target Molecule Corp. 2mg/USD30();10mg/USD73();100mg/USD498() USA
10

Related Products

Other Forms of 154235-83-3

Name CAS No Formula MW

Recommended Compounds in iGluR

Name CAS No Formula MW
PEAQX 459836-30-7 C17H17BrN3O5P 454.2117
Dextromethorphan (hydrobromide) 125-69-9 C18H26BrNO 352.31
Piracetam 7491-74-9 C6H10N2O2 142.16
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Coluracetam 135463-81-9 C19H23N3O3 341.4
NMDA 6384-92-5 C5H9NO4 147.13
Sunifiram 314728-85-3 C14H18N2O2 246.3
SDZ 220-581 (hydrochloride) 179411-93-9 C16H18Cl2NO5P 406.2
Orphenadrine (citrate) 4682-36-4 C24H31NO8 461.5
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Ro 25-6981 (Maleate) 1312991-76-6 C26H33NO6 455.54
Ro 25-6981 169274-78-6 C22H29NO2 339.47
Felbamate (hydrate) 1177501-39-1 C11H16N2O5 256.26
Felbamate 25451-15-4 C11H14N2O4 238.24
Flupirtine 56995-20-1 C15H17FN4O2 304.32
Noopept 157115-85-0 C17H22N2O4 318.37
QNZ46 1237744-13-6 C24H17N3O6 443.4083
SDZ 220-581 (Ammonium salt) 179411-94-0 C16H20ClN2O5P 386.77
MDL-29951 130798-51-5 C12H9Cl2NO4 302.11
MDL 105519 161230-88-2 C18H11Cl2NO4 376.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
Lu AE58054 467459-31-0 C20H19F5N2O 398.37
EVP-6124 550999-75-2 C16H17ClN2OS 320.84
Rifabutin 72559-06-9 C46H62N4O11 847.0
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
PF-2545920 898562-94-2 C25H20N4O 392.45
lumateperone (Tosylate) 1187020-80-9 C31H36FN3O4S 565.6987
Asenapine 65576-45-6 C17H16ClNO 285.77
Tideglusib 865854-05-3 C19H14N2O2S 334.39
Cilostazol 73963-72-1 C20H27N5O2 369.46
Adoprazine 222551-17-9 C24H24FN3O2 405.46
Semagacestat 425386-60-3 C19H27N3O4 361.44
Clozapine 5786-21-0 C18H19ClN4 326.82
SB-742457 607742-69-8 C19H19N3O2S 353.44
Bitopertin 845614-11-1 C21H20F7N3O4S 543.46
Bitopertin (R enantiomer) 845614-12-2 C21H20F7N3O4S 543.46
Masitinib 790299-79-5 C28H30N6OS 498.64
Lurasidone (Hydrochloride) 367514-88-3 C28H37ClN4O2S 529.14
(R)-Baclofen 69308-37-8 C10H12ClNO2 213.66
LY450108 376594-67-1 C19H22F2N2O3S 396.45
11

Route of Synthesis

12

References

13

More Information

Ampalex

Tags: buy 154235-83-3 IC50 | 154235-83-3 price | 154235-83-3 cost | 154235-83-3 solubility | 154235-83-3 purchase | 154235-83-3 manufacturer | 154235-83-3 research buy | 154235-83-3 order | 154235-83-3 MSDS | 154235-83-3 chemical structure | 154235-83-3 Storage condition | 154235-83-3 molecular weight | 154235-83-3 mw | 154235-83-3 datasheet | 154235-83-3 supplier | 154235-83-3 cell line | 154235-83-3 NMR | 154235-83-3 MS | 154235-83-3 IR | 154235-83-3 solubility | 154235-83-3 Safe information | 154235-83-3 Qc and Spectral Information | 154235-83-3 Clinical Information | 154235-83-3 Clinical Trial | 154235-83-3 Route of Synthesis | 154235-83-3 storage condition | 154235-83-3 diseases and conditions | 154235-83-3 flash point | 154235-83-3 boiling point | 154235-83-3 melting point | 154235-83-3 storage condition | 154235-83-3 brand