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102676-31-3 (Fadrozole hydrochloride)

1

Identification

Fadrozole hydrochloride Fadrozole hydrochloride
Name Fadrozole hydrochloride
Formula C14H14ClN3
MW 259.73
CAS No. 102676-31-3
EINECS
Smiles N#CC1=CC=C(C2CCCC3=CN=CN23)C=C1.Cl
Synonyms CGS 16949A
InChI InChI=1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H
2

Introduction

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.

Background Information

Fadrozole?(INN, marketed as?Afema?by?Novartis) is an?aromatase inhibitor?that has been introduced in Japan?for the treatment of?breast cancer. ......by BOC Sciences
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. ......by MedChemexpress Co., Ltd.
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer. ......by MedKoo Biosciences, Inc.
A potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide; lowers ovarian estrogen synthesis by gonadotropin-primed, androstenedione treated mice, suppresses hormone-dependent and -independent tumors in vivo.Breast CancerApproved ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000023846

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fadrozole hydrochloride - No Development Reported
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Safety Data of Fadrozole hydrochloride

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD50();10mg/USD80() USA
Cayman Chemical Company USA
China Jintai Biocompound Company China
MedChemexpress Co., Ltd. 5mg/USD50();10mg/USD80() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD50();10mg/USD80() China
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Related Products

Other Forms of 102676-31-3

Name CAS No Formula MW
Fadrozole 102676-47-1 C14H13N3 223.27

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

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More Information

Fadrozole hydrochloride

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