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241479-67-4 (Isavuconazole)

1

Identification

Isavuconazole Isavuconazole
Name Isavuconazole
Formula C22H17F2N5OS
MW 437.4650864
CAS No. 241479-67-4
EINECS
Smiles FC1=CC=C(F)C=C1[[email protected]](CN2C=NC=N2)(O)[[email protected]@H](C)C3=NC(C4=CC=C(C#N)C=C4)=CS3
Synonyms BAL-4815;RO-0094815
InChI InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
2

Introduction

Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.

Background Information

Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida s ......by BOC Sciences
Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity. ......by MedChemexpress Co., Ltd.
Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023823

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10Mm in DMSO by CHEMSCENE, LLC
10Mm in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Isavuconazole Astellas Pharma Inc Pharmacokinetics of Isavuconazole 2012/8/6 Phase 1 Clinical
Isavuconazole Astellas Pharma Inc Healthy Subjects 2013/6/20 Phase 1 Clinical
Isavuconazole - Phase 3
7

Safety Data of Isavuconazole

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD90();10mg/USD120() USA
MedChemexpress Co., Ltd. 5mg/USD90();10mg/USD120() USA
Pure Chemistry Scientific Inc. 1mg/USD286(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD90();10mg/USD120() China
Target Molecule Corp. 1mg/USD112();5mg/USD320();10mg/USD520();25mg/USD824();50mg/USD1260() USA
10

Related Products

Other Forms of 241479-67-4

Name CAS No Formula MW

Recommended Compounds in Fungal Cytochrome P450

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cenerimod 1262414-04-9 C25H31N3O5 453.53
Vaborbactam 1360457-46-0 C12H16BNO5S 297.14
11

Route of Synthesis

12

References

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More Information

Isavuconazole

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