• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

241479-67-4 (BAL 4815)

1

Identification

BAL 4815 BAL 4815
Name BAL 4815
Formula C22H17F2N5OS
MW 437.47
CAS No. 241479-67-4
EINECS
Smiles FC1=CC=C(F)C=C1[[email protected]](CN2C=NC=N2)(O)[[email protected]@H](C)C3=NC(C4=CC=C(C#N)C=C4)=CS3
Synonyms Isavuconazole; RO 0094815; 4-(2-((2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
InChI InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
2

Introduction

Background Information

Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. IC50 value: Target: antifungal agent in vitro: Isavuconazole was more active (0.004 mg/liter) than amphotericin B (0.5 mg/liter), itraconazole (0.008 mg/liter), voriconazole (0.03 mg/liter), flucytosine (0.125 mg/liter), and fluconazole (8 mg/liter). There were only two isolates with MICs for isavuconazole that were >0.5 mg/liter: both were C. glabrata isolates, and the MICs were 2 and 4 mg/liter, respectively [1]. Isavuconazole has MIC90 value of 0.016 microg/ml against Cryptococcus neoformans isolates from Cuba [2]. Protocol(Only for Reference) [1] Antifungal susceptibility testing: Broth microdilution was performed by the reference method described by the CLSI (formerly National Committee for Clinical Laboratory Standards) in accordance with guideline M27-A2 (5), with a final inoculum concentration of 0.5 × 103 to 2.5 × 103 cells per ml and RPMI 1640 medium (Sigma, Steinheim, Germany) buffered to pH 7.0 with 0.165 M MOPS (morpholinepropanesulfonic acid) buffer (Merck, Darmstadt, Germany). Microtiter plates containing dehydrated antifungal agents were provided by Merlin Diagnostica (Bornheim-Hersel, Germany). The antifungal agents and concentration ranges tested in twofold steps were as follows: amphotericin B, 0.03 to 32 mg/liter; flucytosine, 0.03 to 64 mg/liter; fluconazole, 0.06 to 128 mg/liter; itraconazole, 0.004 to 8 mg/liter; voriconazole, 0.004 to 8 mg/liter; and isavuconazole, 0.00025 to 8 mg/liter. Plates were incubated in air at 35°C for 24 to 48 h. Plates were observed for the presence or absence of growth at 24 h and reexamined at 48 h if sufficient growth was not obtained at 24 h. The MIC was determined visually as the lowest concentration of drug showing no growth for amphotericin B and a prominent reduction of growth (≥50%) for flucytosine and the azoles compared to the drug-free growth control. C. parapsilosis ATCC 22019 and C. krusei ATCC 6258 were used as quality control strains. ......by MedChemexpress Co., Ltd.
Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023823

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10Mm in DMSO by CHEMSCENE, LLC
10Mm in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
BAL 4815 Astellas Pharma Inc Pharmacokinetics of Isavuconazole 2012/8/6 Phase 1 Clinical
BAL 4815 Astellas Pharma Inc Healthy Subjects 2013/6/20 Phase 1 Clinical
BAL 4815 - Phase 3
7

Safety Data of BAL 4815

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 1mg/USD180(In stock);5mg/USD780(In stock) USA
Pure Chemistry Scientific Inc. 1mg/USD286(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Target Molecule Corp. 1mg/USD112();5mg/USD320();10mg/USD520();25mg/USD824();50mg/USD1260() USA
10

Related Products

Other Forms of 241479-67-4

Name CAS No Formula MW

Recommended Compounds in Fungal Cytochrome P450

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cenerimod 1262414-04-9 C25H31N3O5 453.53
Vaborbactam 1360457-46-0 C12H16BNO5S 297.14
11

Route of Synthesis

12

References

13

More Information

BAL 4815

Tags: buy 241479-67-4 IC50 | 241479-67-4 price | 241479-67-4 cost | 241479-67-4 solubility | 241479-67-4 purchase | 241479-67-4 manufacturer | 241479-67-4 research buy | 241479-67-4 order | 241479-67-4 MSDS | 241479-67-4 chemical structure | 241479-67-4 Storage condition | 241479-67-4 molecular weight | 241479-67-4 mw | 241479-67-4 datasheet | 241479-67-4 supplier | 241479-67-4 cell line | 241479-67-4 NMR | 241479-67-4 MS | 241479-67-4 IR | 241479-67-4 solubility | 241479-67-4 Safe information | 241479-67-4 Qc and Spectral Information | 241479-67-4 Clinical Information | 241479-67-4 Clinical Trial | 241479-67-4 Route of Synthesis | 241479-67-4 storage condition | 241479-67-4 diseases and conditions | 241479-67-4 flash point | 241479-67-4 boiling point | 241479-67-4 melting point | 241479-67-4 storage condition | 241479-67-4 brand