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241479-67-4 (Isavuconazole)

1

Identification

Isavuconazole Isavuconazole
Name Isavuconazole
Formula C22H17F2N5OS
MW 437.4650864
CAS No. 241479-67-4
EINECS
Smiles FC1=CC=C(F)C=C1[[email protected]](CN2C=NC=N2)(O)[[email protected]@H](C)C3=NC(C4=CC=C(C#N)C=C4)=CS3
Synonyms BAL-4815;RO-0094815
InChI InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
2

Introduction

Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.

Background Information

Isavuconazole is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. ......by AdooQ BioScience, LLC
Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida s ......by BOC Sciences
Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity. ......by MedChemexpress Co., Ltd.
Isavuconazole, also knownc as BAL4815 and RO 0094815, is a triazole antifungal drug. Its prodrug, isavuconazonium sulfate (BAL8557), was granted approval by the U.S. Food and Drug Administration (FDA) on March 6, 2015 for the treatment of invasive candidiasis. Isavuconazole works by inhibiting lanosterol 14 alpha-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and build up of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi. ......by MedKoo Biosciences, Inc.
Isavuconazole is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis. ......by Selleck Chemicals LLC
Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023823

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10Mm in DMSO by CHEMSCENE, LLC
10Mm in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Isavuconazole Astellas Pharma Inc Pharmacokinetics of Isavuconazole 2012/8/6 Phase 1 Clinical
Isavuconazole Astellas Pharma Inc Healthy Subjects 2013/6/20 Phase 1 Clinical
Isavuconazole - Phase 3
7

Safety Data of Isavuconazole

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD90();10mg/USD120() USA
MedChemexpress Co., Ltd. 5mg/USD90();10mg/USD120() USA
MedKoo Biosciences, Inc. USA
Pure Chemistry Scientific Inc. 1mg/USD286(In stock) USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD90();10mg/USD120() China
Target Molecule Corp. 1mg/USD112();5mg/USD320();10mg/USD520();25mg/USD824();50mg/USD1260() USA
10

Related Products

Other Forms of 241479-67-4

Name CAS No Formula MW

Recommended Compounds in Fungal Cytochrome P450

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cenerimod 1262414-04-9 C25H31N3O5 453.53
Vaborbactam 1360457-46-0 C12H16BNO5S 297.14
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Route of Synthesis

12

References

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More Information

Isavuconazole

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