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616202-92-7 (Lorcaserin)

1

Identification

Lorcaserin Lorcaserin
Name Lorcaserin
Formula C11H14ClN
MW 195.69
CAS No. 616202-92-7
EINECS
Smiles C[[email protected]]1CNCCC2=CC=C(Cl)C=C12
Synonyms APD-356;APD 356;APD356; (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
2

Introduction

Lorcaserin(APD356) is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. IC50 value: 15 nM (Ki, Human 5-HT2c); 29 nM (Ki, Rat 5-HT2c) [1] Target: 5-HT2c receptor in vitro: lorcaserin, a selective, high affinity 5-HT(2C) full agonist.

Background Information

Lorcaserin is a Novel Selective Human 5-Hydroxytryptamine2C Agonist ......by AdooQ BioScience, LLC
Lorcaserin is an orally active, small-molecule 5-hydroxytryptamine 2C agonist for the potential treatment of obesity and diabetes. ......by MedKoo Biosciences, Inc.
Lorcaserin(APD356) is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow oil EBNumber:EB000023719

Storage condition

Solubility

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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lorcaserin Eisai Inc Obesity 2013/10/31 2014/7/31 Phase 4 Clinical
Lorcaserin Southern California Institute for Research and Education Weight gain 2014/1/31 2015/7/1 Phase 4 Clinical
Lorcaserin Arena Pharmaceuticals Inc Obesity 2008/1/31 2009/8/31 Phase 3 Clinical
Lorcaserin Arena Pharmaceuticals Inc Obesity 2006/11/30 2009/2/28 Phase 3 Clinical
Lorcaserin Arena Pharmaceuticals Inc Obesity 2007/12/27 2010/10/31 Phase 3 Clinical
Lorcaserin - Launched
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Safety Data of Lorcaserin

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 616202-92-7

Name CAS No Formula MW
Lorcaserin (Hydrochloride) 846589-98-8 C11H15Cl2N 232.15
Lorcaserin (hydrochloride Hemihydrate) 856681-05-5 C11H16Cl2NO0.5 241.16

Recommended Compounds in 5-HT Receptor

Name CAS No Formula MW
RU 24969 66611-26-5 C14H16N2O 228.29
Eltoprazine (hydrochloride) 98206-09-8 C12H17ClN2O2 256.73
Eltoprazine 98224-03-4 C12H16N2O2 220.27
Dolasetron 115956-12-2 C19H20N2O3 324.37
Cyclobenzaprine (hydrochloride) 6202-23-9 C20H22ClN 311.85
Dihydroergotamine (mesylate) 6190-39-2 C34H41N5O8S 679.78
Ramosetron (Hydrochloride) 132907-72-3 C17H18ClN3O 315.8
Alverine (citrate) 5560-59-8 C26H35NO7 473.56
Trazodone (hydrochloride) 25332-39-2 C19H23Cl2N5O 408.32
Clomipramine (hydrochloride) 17321-77-6 C19H24Cl2N2 351.31
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Almotriptan (malate) 181183-52-8 C21H31N3O7S 469.55
Cyproheptadine (hydrochloride) 969-33-5 0.0
Urapidil (hydrochloride) 64887-14-5 C20H30ClN5O3 423.94
Mirtazapine 85650-52-8 C17H19N3 265.35
Zolmitriptan 139264-17-8 C16H21N3O2 287.36
Rizatriptan (benzoate) 145202-66-0 C22H25N5O2 391.47
Naratriptan 121679-13-8 0.0
Mosapride 112885-41-3 C21H25ClFN3O3 421.89
Mosapride (citrate) 112885-42-4 C27H37ClFN3O12 650.05

Recommended Compounds in Same Indication

Name CAS No Formula MW
AZD7687 1166827-44-6 C21H25N3O3 367.44
Lorcaserin (Hydrochloride) 846589-98-8 C11H15Cl2N 232.15
Octreotide (acetate) 79517-01-4 C51H70N10O12S2 1079.29
Otenabant 686344-29-6 C25H25Cl2N7O 510.42
Otenabant (Hydrochloride) 686347-12-6 C25H26Cl3N7O 546.88
Taranabant 701977-09-5 C27H25ClF3N3O2 515.95
PF-04620110 1109276-89-2 C21H24N4O4 396.44
Rimonabant 168273-06-1 C22H21Cl3N4O 463.79
Rimonabant (Hydrochloride) 158681-13-1 C22H22Cl4N4O 500.25
Olanzapine 132539-06-1 C17H20N4S 312.43
MK-0557 328232-95-7 C22H19FN4O3 406.4097
BRADYKININ 58-82-2 C50H73N15O11 1060.21
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Route of Synthesis

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References

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More Information

Lorcaserin

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