• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

446859-33-2 (RepSox)

1

Identification

RepSox RepSox
Name RepSox
Formula C17H13N5
MW 287.32
CAS No. 446859-33-2
EINECS
Smiles CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
Synonyms E-616452;SJN 2511;E616452;SJN2511;E 616452;SJN-2511; 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
InChI InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
2

Introduction

RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. IC50 Value: 23 nM Target: ALK5 in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction with Oct4, Klf4, and cMyc.

Background Information

Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β type I receptor (TGF-β R1, Alk5) ......by AOBIOUS INC
RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor, inhibits ALK5 autophosphorylation with IC50 of 4 nM. ......by MedChemexpress Co., Ltd.
RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. ......by Selleck Chemicals LLC
RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000023583

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
DMSO 57 mg/mL (198 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol <1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
RepSox - Not Found
RepSox - No Development Reported
7

Safety Data of RepSox

Hazard Symbols : T
Risk Statements : 25
Safety Statements : 45
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD15() USA
Active Biopharma Corp China
Alfa Chemistry USA
BOC Sciences 100mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD72();10mg/USD108() USA
MedChemexpress Co., Ltd. 5mg/USD72();10mg/USD108() USA
Selleck Chemicals LLC 10mg/USD147(In stock);25mg/USD270(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD72();10mg/USD108() China
Target Molecule Corp. 5mg/USD63();10mg/USD124();25mg/USD183();50mg/USD343() USA
10

Related Products

Other Forms of 446859-33-2

Name CAS No Formula MW

Recommended Compounds in TGF-β Receptor

Name CAS No Formula MW
K02288 1431985-92-0 C20H20N2O4 352.3838
ML347 1062368-49-3 C22H16N4O 352.39
DMH-1 1206711-16-1 C24H20N4O 380.44
LDN-212854 1432597-26-6 C25H22N6 406.48
SB-505124 (hydrochloride) 356559-13-2 C20H22ClN3O2 371.86
A 77-01 607737-87-1 C18H14N4 286.33
SB-505124 694433-59-5 C20H21N3O2 335.4
LY-364947 396129-53-6 C17H12N4 272.3
LDN193189 (Hydrochloride) 1062368-62-0 C25H26Cl4N6 552.33
SD-208 627536-09-8 C17H10ClFN6 352.75
LDN193189 1062368-24-4 C25H22N6 406.48
A 83-01 909910-43-6 C25H19N5S 421.52
LY2109761 700874-71-1 C26H27N5O2 441.52
LY2157299 700874-72-2 C22H19N5O 369.42
GW788388 452342-67-5 C25H23N5O2 425.48
SB 525334 356559-20-1 C21H21N5 343.42
SB-431542 301836-41-9 C22H16N4O3 384.39
EW-7197 1352608-82-2 C22H18FN7 399.42
R-268712 879487-87-3 C20H18FN5O 363.39
ITD-1 1099644-42-4 C27H29NO3 415.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

RepSox

Tags: buy 446859-33-2 IC50 | 446859-33-2 price | 446859-33-2 cost | 446859-33-2 solubility | 446859-33-2 purchase | 446859-33-2 manufacturer | 446859-33-2 research buy | 446859-33-2 order | 446859-33-2 MSDS | 446859-33-2 chemical structure | 446859-33-2 Storage condition | 446859-33-2 molecular weight | 446859-33-2 mw | 446859-33-2 datasheet | 446859-33-2 supplier | 446859-33-2 cell line | 446859-33-2 NMR | 446859-33-2 MS | 446859-33-2 IR | 446859-33-2 solubility | 446859-33-2 Safe information | 446859-33-2 Qc and Spectral Information | 446859-33-2 Clinical Information | 446859-33-2 Clinical Trial | 446859-33-2 Route of Synthesis | 446859-33-2 storage condition | 446859-33-2 diseases and conditions | 446859-33-2 flash point | 446859-33-2 boiling point | 446859-33-2 melting point | 446859-33-2 storage condition | 446859-33-2 brand