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627536-09-8 (SD-208)

1

Identification

SD-208 SD-208
Name SD-208
Formula C17H10ClFN6
MW 352.75
CAS No. 627536-09-8
EINECS
Smiles FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2
Synonyms SD 208; SD208; 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
InChI InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
2

Introduction

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. IC50 value: 49 nM Target: TGF-βRI SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

Background Information

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. IC50 value: 49 nM Target: TGF-βRI SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII. SD-208 exhibits anti-inflammatory and antitumor activity. ......by MedChemexpress Co., Ltd.
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:yellow to yellow-brown solid EBNumber:EB000023531

Storage condition

Solubility

DMSO >10 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SD-208 - No Development Reported
7

Safety Data of SD-208

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 10mg/USD118(Ship Within 10-14 Days);50mg/USD498(Ship Within 10-14 Days) USA
Axon Medchem BV 2mg/USD72(In Stock) Netherlands
CHEMSCENE, LLC USA
Cayman Chemical Company 1mg/USD29() USA
EMD Millipore 2mg/USD119() USA
KareBay Biochem 10mg/USD125() USA
MedChemexpress Co., Ltd. 10mg/USD124(In stock);50mg/USD524(In stock) USA
Pure Chemistry Scientific Inc. 10mg/USD65(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD124(In stock);50mg/USD524(In stock) China
Sigma-Aldrich, Inc. 5mg/USD142() USA
Target Molecule Corp. 2mg/USD66();5mg/USD112();10mg/USD198();50mg/USD476();100mg/USD735() USA
Tocris Bioscience Inc. 10mg/USD165() USA
10

Related Products

Other Forms of 627536-09-8

Name CAS No Formula MW

Recommended Compounds in TGF-β Receptor

Name CAS No Formula MW
K 02288 1431985-92-0 C20H20N2O4 352.38
ML347 1062368-49-3 C22H16N4O 352.39
DMH-1 1206711-16-1 C24H20N4O 380.44
LDN-212854 1432597-26-6 C25H22N6 406.48
SB-505124 (hydrochloride) 356559-13-2 C20H22ClN3O2 371.86
A 77-01 607737-87-1 C18H14N4 286.33
SB-505124 694433-59-5 C20H21N3O2 335.4
LY-364947 396129-53-6 C17H12N4 272.3
LDN193189 (Hydrochloride) 1062368-62-0 C25H26Cl4N6 552.33
RepSox 446859-33-2 C17H13N5 287.32
LDN193189 1062368-24-4 C25H22N6 406.48
A 83-01 909910-43-6 C25H19N5S 421.52
LY2109761 700874-71-1 C26H27N5O2 441.52
LY2157299 700874-72-2 C22H19N5O 369.42
GW788388 452342-67-5 C25H23N5O2 425.48
SB 525334 356559-20-1 C21H21N5 343.42
SB-431542 301836-41-9 C22H16N4O3 384.39
EW-7197 1352608-82-2 C22H18FN7 399.42
R-268712 879487-87-3 C20H18FN5O 363.39
ITD-1 1099644-42-4 C27H29NO3 415.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

SD-208

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