• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

80621-81-4 (Rifaximin)

1

Identification

Rifaximin Rifaximin
Name Rifaximin
Formula C43H51N3O11
MW 785.88
CAS No. 80621-81-4
EINECS
Smiles CC1=CC(N2C=C1)=NC3=C2C(NC(/C(C)=CC=C[[email protected]](C)[[email protected]](O)[[email protected]@H](C)[[email protected]@H](O)[[email protected]@H](C)[[email protected]](OC(C)=O)[[email protected]@H](C)[[email protected]](OC)/C=CO[[email protected]@](C4=O)(C)O5)=O)=C(O)C6=C(O)C(C)=C5C4=C63
Synonyms Xifaxan;
InChI InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15-,21-13-/t20-,22-,23+,24+,27+,35-,36+,39+,43-/m0/s1
2

Introduction

Rifaximin(Xifaxan) is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. IC50 Value: Target: RNA polymerase; antibacterial Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that very little of the drug will pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics.

Background Information

Rifaximin, an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. ......by BOC Sciences
Rifaximin(Xifaxan), an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth. As rifaximin is not well absorbed, its antibacterial activity is largely localized to the gastrointestinal tract. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow solid EBNumber:EB000023528

Storage condition

Solubility

DMSO >40 mg/mL Ethanol >100 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Rifaximin Tampa General Hospital Hepatic encephalopathy 2013/4/30 Phase 4 Clinical
Rifaximin Tampa General Hospital Liver cirrhosis 2013/4/30 Phase 4 Clinical
Rifaximin Salix Pharmaceuticals Ltd Hepatic encephalopathy 2013/1/31 2014/6/30 Phase 4 Clinical
Rifaximin Copenhagen University Hospital, Hvidovre Liver cirrhosis 2012/11/30 2015/5/31 Phase 4 Clinical
Rifaximin Imperial College London Non alcoholic fatty liver disease 2011/5/31 2012/9/30 Phase 4 Clinical
Rifaximin Imperial College London Non-alcoholic steatohepatitis 2011/5/31 2012/9/30 Phase 4 Clinical
Rifaximin - Launched
7

Safety Data of Rifaximin

RTECS : KD1576000
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Abcam 50mg/USD139() USA
AdooQ BioScience, LLC 100mg/USD60() USA
Apexbio Technology LLC 500mg/USD53(In stock) USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 500mg/USD60();1g/USD96() USA
Cayman Chemical Company 100mg/USD35() USA
Chem-Cook Chemicals Ltd. China
Hebei Xingang Pharmaceutical Co., Ltd. China
Herb King Pharmaceutical Group CHINA
Linhai Haixing Chemical Factory China
MedChemexpress Co., Ltd. 500mg/USD60();1g/USD96() USA
Santa Cruz Biotechnology, Inc. 500mg/USD75() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 500mg/USD60();1g/USD96() China
Sigma-Aldrich, Inc. 1g/USD110() USA
Target Molecule Corp. 2mg/USD20();10mg/USD45();50mg/USD78();200mg/USD122() USA
Tocris Bioscience Inc. 50mg/USD49() USA
Tokyo Chemical Industry Co., Ltd. 1g/USD88() Japan
Toronto Research Chemicals Inc. 100mg/USD45() Canada
VDM BIOCHEMICALS,Inc. 100mg/USD50() USA
Zhejiang Sixian Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 80621-81-4

Name CAS No Formula MW

Recommended Compounds in Bacterial

Name CAS No Formula MW
Fidaxomicin 873857-62-6 C52H74Cl2O18 1058.04
AVX 13616 900814-48-4 C50H73Cl2N7O7 955.06
Bedaquiline (fumarate) 845533-86-0 C36H35BrN2O6 671.58
Mafenide (Acetate) 13009-99-9 C9H14N2O4S 246.28
Cefozopran 113359-04-9 C19H17N9O5S2 515.53
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Pazufloxacin 127045-41-4 C16H15FN2O4 318.3
Pazufloxacin (mesylate) 163680-77-1 C17H19FN2O7S 414.4054
Capreomycin (sulfate) 1405-37-4 C24H44N14O12S 752.76
Bleomycin (sulfate) 9041-93-4 C110H168N34O46S7 2927.17
G-418 (disulfate) 108321-42-2 C20H44N4O18S2 692.71
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Apramycin 37321-09-8 C21H41N5O11 539.58
Ceftriaxone 73384-59-5 C18H18N8O7S3 554.58
Ceftibuten 97519-39-6 C15H14N4O6S2 410.42
Dapsone 80-08-0 C12H12N2O2S 248.3
Vancomycin 1404-90-6 C66H76Cl3N9O24 1485.72
Lomefloxacin 98079-51-7 C17H19F2N3O3 351.35
Dirithromycin 62013-04-1 C42H78N2O14 835.07
Cefepime (Dihydrochloride Monohydrate) 123171-59-5 C19H28Cl2N6O6S2 571.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
(Z)-Olesoxime 66514-00-9 C27H45NO 399.6523
Silibinin 22888-70-6 C25H22O10 482.44
Tolvaptan 150683-30-0 C26H25ClN2O3 448.94
LCQ-908 956136-95-1 C25H24F3N3O2 455.47
Heparin 9005-49-6 C26H42N2O37S5 1134.93
11

Route of Synthesis

12

References

13

More Information

Rifaximin

Tags: buy 80621-81-4 IC50 | 80621-81-4 price | 80621-81-4 cost | 80621-81-4 solubility | 80621-81-4 purchase | 80621-81-4 manufacturer | 80621-81-4 research buy | 80621-81-4 order | 80621-81-4 MSDS | 80621-81-4 chemical structure | 80621-81-4 Storage condition | 80621-81-4 molecular weight | 80621-81-4 mw | 80621-81-4 datasheet | 80621-81-4 supplier | 80621-81-4 cell line | 80621-81-4 NMR | 80621-81-4 MS | 80621-81-4 IR | 80621-81-4 solubility | 80621-81-4 Safe information | 80621-81-4 Qc and Spectral Information | 80621-81-4 Clinical Information | 80621-81-4 Clinical Trial | 80621-81-4 Route of Synthesis | 80621-81-4 storage condition | 80621-81-4 diseases and conditions | 80621-81-4 flash point | 80621-81-4 boiling point | 80621-81-4 melting point | 80621-81-4 storage condition | 80621-81-4 brand