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161735-79-1 (Rasagiline (mesylate))

1

Identification

Rasagiline (mesylate) Rasagiline (mesylate)
Name Rasagiline (mesylate)
Formula C13H17NO3S
MW 267.34
CAS No. 161735-79-1
EINECS
Smiles C#CCN[[email protected]](CC1)C2=C1C=CC=C2.O=S(O)(C)=O
Synonyms (R)-N-2-Propynyl-1-indanamine methanesulfonate; (R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate
InChI InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
2

Introduction

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

Background Information

Rasagiline is an irreversible inhibitor of monoamine oxidase used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. It is selective for MAO type B over type A by a factor of fourteen. ......by AdooQ BioScience, LLC
Rasagiline (N-propargyl-1-(R)-aminoindan) is a novel, highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug. ......by BOC Sciences
Rasagiline is a selective and irreversible inhibitor of monoamine oxidase (MAO) that has been used as a monotherapy in early Parkinson’s disease or as an adjunct therapy in more advanced cases. ......by BioVision, Inc.,
Rasagiline Mesylate is a selective irreversible MAO-B inhibitor. It displays anti-Parkinsonian activity, exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture. ......by MedKoo Biosciences, Inc.
Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. ......by Selleck Chemicals LLC
Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. ......by Target Molecule Corp.
Selective irreversible MAO-B inhibitor. Displays antiParkinsonian activity; exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023115

Storage condition

Solubility

DMSO 53 mg/mL; Water 53 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 53 mg/mL (198.24 mM); Water53 mg/mL (198.24 mM); Ethanol53 mg/mL (198.24 mM); In vivo Saline30 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling Autophagy
Target Autophagy Monoamine Oxidase
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Rasagiline (mesylate) - Launched
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Safety Data of Rasagiline (mesylate)

Hazard Symbols : Xn
Risk Statements : 22
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Abcam 10mg/USD45() USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing FaMuRuiSi Pharmaceuticals Co., Ltd. China
Beijing Hony Biopharma Technology Co., Ltd. China
Beijing Huafeng United Technology Co., Ltd. China
Beijing Mesochem Technology Co., Ltd. China
BioVision, Inc., 50mg/USD55() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD60();100mg/USD90() USA
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD90() USA
MedKoo Biosciences, Inc. USA
Reco Tech Limited China
Santa Cruz Biotechnology, Inc. 25mg/USD125() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD130(in 1mL DMSO) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD90() China
Shanghai Me-too Pharma Tech Co., Ltd. China
Sigma-Aldrich, Inc. 10mg/USD76() USA
Target Molecule Corp. 1mg/USD24() USA
Tocris Bioscience Inc. 50mg/USD59() USA
Toronto Research Chemicals Inc. 10mg/USD50() Canada
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD128() China
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Related Products

Other Forms of 161735-79-1

Name CAS No Formula MW
Rasagiline 136236-51-6 C12H13N 171.24
Rasagiline 13C3 (mesylate racemic) 1216757-55-9 C10(13C)3H17NO3S 270.32
Rasagiline mesylate (racemic) 1400989-19-6 C13H17NO3S 267.34

Recommended Compounds in Autophagy Monoamine Oxidase

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Rasagiline (mesylate)

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