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599-79-1 (Sulfasalazine)

1

Identification

Sulfasalazine Sulfasalazine
Name Sulfasalazine
Formula C18H14N4O5S
MW 398.39
CAS No. 599-79-1
EINECS 209-974-3
Smiles O=S(C1=CC=C(/N=N/C2=CC=C(O)C(C(O)=O)=C2)C=C1)(NC3=CC=CC=N3)=O
Synonyms 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid; 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid; Salazosulfapyridine; Sulfasalazine; (E)-2-hydroxy-5-((4-(N-(pyridin-2-yl)sulfamoyl)phenyl)diazenyl)benzoic acid
InChI InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
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Introduction

Sulfasalazine, a sulfa agent and a derivative of mesalazine, is used primarily as an anti-inflammatory agent. Target: Others Sulfasalazine (Azulfidine), used to treat pain and swelling in arthritis, belongs to a class of drugs called sulfa drugs.

Background Information

Sulfasalazine (brand name Azulfidine) is a sulfa agent and a derivative of mesalazine. Sulfasalazine inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1. Sulfasalazine also inhibits the cystine-glutamate antiporter, system Xc (SXC). Sulfasalazine, and its metabolite 5-ASA, are poorly absorbed from the gut. Its main mode of action is therefore believed to be inside the intestine. Sulfasalazine (Salazopyrin) induced T lymphocyte apoptosis in glioblastoma cell lines, modulated inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuated transcription of proinflammatory cytokines, and activated PPARγ. Sulfasalazine has long been used in treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. ......by AbMole BioScience
Sulfasalazine (brand name Azulfidine in the U.S., Salazopyrin and Sulazine in Europe and Hong Kong) was developed in the 1950s specifically to treat rheumatoid arthritis.Sulfasalazine is a sulfa agent and a derivative of mesalazine used primarily as an an ......by BOC Sciences
Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity. ......by MedChemexpress Co., Ltd.
Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is also indicated for use in rheumatoid arthritis and used in other types of inflammatory arthritis (e.g. psoriatic arthritis) where it has a beneficial effect. It is often well tolerated compared to other DMARDs. In clinical trials for the treatment of chronic alcoholics, sulfasalazine has been found to reverse the scarring associated with liver cirrhosis. ......by MedKoo Biosciences, Inc.
Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. ......by Selleck Chemicals LLC
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) ......by Target Molecule Corp.
Inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Anti-inflammatory. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:light yellow to khaki Solid EBNumber:EB000023068

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO 80 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 80 mg/mL (200.8 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways NF-κB Autophagy
Target Autophagy NF-κB
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Sulfasalazine - Launched
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Safety Data of Sulfasalazine

Hazard Symbols : Xn
Risk Statements : 42/43
Safety Statements : 22-29/56-45
RTECS : VO6250000
WGKGermany : 2
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
American Custom Chemicals Corp. USA
Anhui Jixi Huihuang Chemical Co., Ltd. China
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD60();5g/USD96() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 1g/USD60();5g/USD96() USA
MedKoo Biosciences, Inc. USA
Pure Chemistry Scientific Inc. 1g/USD30(In stock) USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD96() China
Target Molecule Corp. 10mg/USD56();50mg/USD102();200mg/USD153() USA
Tocris Bioscience Inc. USA
Xinzhen Zhendong Chemical Plant China
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Related Products

Other Forms of 599-79-1

Name CAS No Formula MW

Recommended Compounds in Autophagy NF-κB

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Sulfasalazine

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