• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

870093-23-5 (Talarozole (R enantiomer))

1

Identification

Talarozole (R enantiomer) Talarozole (R enantiomer)
Name Talarozole (R enantiomer)
Formula C21H23N5S
MW 377.5058
CAS No. 870093-23-5
EINECS
Smiles CCC(CC)[[email protected]](C1=CC=C(NC2=NC3=CC=CC=C3S2)C=C1)N4N=CN=C4
Synonyms (R)-Talarozole
InChI InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)/t20-/m1/s1
2

Introduction

Talarozole, also known as R115866, is a CYP26 inhibitor under development for the treatment of acne, psoriasis and other keratinization disorders. Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Because of this mechanism, it is called a retinoic acid metabolism blocking agent (RAMBA).

Background Information

Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. ......by AdooQ BioScience, LLC
Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases including psoriasis and acne. ......by BOC Sciences
Talarozole, also known as R115866, is a CYP26 inhibitor under development for the treatment of acne, psoriasis and other keratinization disorders. Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Because of this mechanism, it is called a retinoic acid metabolism blocking agent (RAMBA). ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000022961

Storage condition

Solubility

DMSO: ≥ 51 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 51 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target Cytochrome P450
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Talarozole (R enantiomer) - No Development Reported
7

Safety Data of Talarozole (R enantiomer)

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1mg/USD228();5mg/USD468() USA
MedChemexpress Co., Ltd. 1mg/USD228();5mg/USD468() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1mg/USD228();5mg/USD468() China
10

Related Products

Other Forms of 870093-23-5

Name CAS No Formula MW
Talarozole 201410-53-9 C21H23N5S 377.51

Recommended Compounds in Cytochrome P450

Name CAS No Formula MW
Dafadine-A 1065506-69-5 C23H25N3O3 391.46
VT-464 (racemate) 1375603-36-3 C18H17F4N3O3 399.34
VT-464 1610537-15-9 C18H17F4N3O3 399.34
Isosilybin 72581-71-6 C25H22O10 482.44
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Clarithromycin 81103-11-9 C38H69NO13 747.95
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.43
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.4309
Galangin 548-83-4
Bergapten 484-20-8 C12H8O4 216.19
Naringin 10236-47-2 C27H32O14 580.53
Diosmetin 520-34-3 C16H12O6 300.26
Fenofibrate 49562-28-9 C20H21ClO4 360.83
Bergaptol 486-60-2 C11H6O4 202.1629
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
Talarozole 201410-53-9 C21H23N5S 377.51
Isavuconazole 241479-67-4 C22H17F2N5OS 437.4650864
Cobicistat 1004316-88-4 C40H53N7O5S2 776.02
Methoxsalen 298-81-7 C12H8O4 216.19
TAK-700 (R-form) 752243-39-3 C18H17N3O2 307.35

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Talarozole (R enantiomer)

Tags: buy 870093-23-5 IC50 | 870093-23-5 price | 870093-23-5 cost | 870093-23-5 solubility | 870093-23-5 purchase | 870093-23-5 manufacturer | 870093-23-5 research buy | 870093-23-5 order | 870093-23-5 MSDS | 870093-23-5 chemical structure | 870093-23-5 Storage condition | 870093-23-5 molecular weight | 870093-23-5 mw | 870093-23-5 datasheet | 870093-23-5 supplier | 870093-23-5 cell line | 870093-23-5 NMR | 870093-23-5 MS | 870093-23-5 IR | 870093-23-5 solubility | 870093-23-5 Safe information | 870093-23-5 Qc and Spectral Information | 870093-23-5 Clinical Information | 870093-23-5 Clinical Trial | 870093-23-5 Route of Synthesis | 870093-23-5 storage condition | 870093-23-5 diseases and conditions | 870093-23-5 flash point | 870093-23-5 boiling point | 870093-23-5 melting point | 870093-23-5 storage condition | 870093-23-5 brand