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529-44-2 (Myricetin)

1

Identification

Myricetin Myricetin
Name Myricetin
Formula C15H10O8
MW 318.2351
CAS No. 529-44-2
EINECS 208-463-2
Smiles OC1=CC(O)=C(C(C(O)=C(C2=CC(O)=C(O)C(O)=C2)O3)=O)C3=C1
Synonyms Cannabiscetin
InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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Introduction

Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.

Background Information

Inhibitor of DNA Polymerase III Holoenzyme System, Primase ......by AOBIOUS INC
Myricetin (Cannabiscetin) is a naturally occurring flavonol, a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. ......by AdooQ BioScience, LLC
Myricetin is an ATP-competitive inhibitor of PI 3-kinaseα. Myricetin is a flavonoid compound found in many fruits and vegetables, including red wine, that acts as a powerful antioxidant. Myricetin inhibits TBARS formation with an IC50 value of 6.34 and at 20 μM, blocks oxLDL uptake by U937-derived macrophages, reducing CD36 expression. Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting ME ......by Affix Scientific
Myricetin is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic c ......by BOC Sciences
Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. ......by MedChemexpress Co., Ltd.
Myricetin is a COMT inhibitor found in fruits and vegetables. It exhibits a wide variety of biological activities, including decreasing cholesterol, triglyceride, and lipid levels, inhibiting amyloid-B-induced neurodegeneration, activating Wnt/B-catenin signaling to increase osteoclast differentiation, and inducing cell cycle arrest in oral squamous cell carcinoma cells. ......by MedKoo Biosciences, Inc.
Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM. ......by Selleck Chemicals LLC
Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). ......by Target Molecule Corp.
Irreversible TrxR inhibitor (IC50 = 0.62 μM). Exhibits concentration-, time- and NADH-dependent TrxR inhibition. Results in the oxidation of Trx and reduced TrxR activity in vitro in addition to the accumulation of cells in sub-G1 phase. Reduces neoplastic transformation and induces cell death in cancer cell lines. Chemotherapeutic. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000022680

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

DMSO: ≥ 31 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 31 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 63 mg/mL (197.96 mM); Ethanol20 mg/mL warming (62.84 mM); Water<1 mg/mL (<1 mM); In vivo 4% DMSO+30% PEG 300+ddH2O5mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Apoptosis
Target Apoptosis
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Myricetin - No Development Reported
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Safety Data of Myricetin

Safety Statements : 24/25
RTECS : LK8646000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AOBIOUS INC USA
AOBIOUS INC USA
AdooQ BioScience, LLC USA
Affix Scientific 1g/USD350(In stock);5g/USD750(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
Biogen Science & Technology Co., Ltd. China
CHEMSCENE, LLC 50mg/USD60();100mg/USD84() USA
Cactus Botanics (Shanghai) Co., Ltd. China
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD84() USA
MedKoo Biosciences, Inc. USA
Ningbo Dekang Biochem Co., Ltd. China
Pure Chemistry Scientific Inc. 100mg/USD156(In stock) USA
Selleck Chemicals LLC 25mg/USD50(In stock);10mM/1mLIn DMSO/USD70(In stock);100mg/USD120(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD84() China
Target Molecule Corp. 5mg/USD27();50mg/USD198();100mg/USD345() USA
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 529-44-2

Name CAS No Formula MW

Recommended Compounds in Apoptosis

Name CAS No Formula MW
Epibrassinolide 78821-43-9 C28H48O6 480.68
Columbianadin 5058-13-9 C19H20O5 328.36
NSC348884 81624-55-7 C38H40N10 636.79
SMIP004 143360-00-3 C13H19NO 205.3
Meisoindigo 97207-47-1 C17H12N2O2 276.29
Betulin 473-98-3 C30H50O2 442.72
Costunolide 553-21-9 C15H20O2 232.32
Baohuoside I 113558-15-9 C27H30O10 514.52
Bisdemethoxycucurmin 24939-16-0 C19H16O4 308.3279
Demethoxycurcumin 22608-11-3 C20H18O5 338.35
Cisplatin 15663-27-1 Cl2H6N2Pt 300.05
(E)-[6]-Dehydroparadol 878006-06-5 C17H24O3 276.3707
PM00104 308359-57-1 C37H38F3N3O8 709.71
Episilvestrol 697235-39-5 C34H38O13 654.66
Trabectedin 114899-77-3 C39H43N3O11S 761.84
Adarotene 496868-77-0 C25H26O3 374.47
(±)-[6]-Gingerol 39886-76-5 C17H26O4 294.3859
Betulinic acid 472-15-1 C30H48O3 456.7
Silvestrol aglycone 960365-65-5 C27H26O8 478.4905
Elesclomol 488832-69-5 C19H20N4O2S2 400.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Myricetin

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