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4759-48-2 (Isotretinoin)

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Identification

Isotretinoin Isotretinoin
Name Isotretinoin
Formula C20H28O2
MW 300.44
CAS No. 4759-48-2
EINECS 225-296-0
Smiles CC(/C=C/C=C(C=CC1=C(CCCC(C)1C)C)C)=C/C(O)=O
Synonyms 13-cis-Retinoic acid; 13-cis-Vitamin A acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid; (2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14-
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Introduction

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.

Background Information

Isotretinoin, also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is an oral pharmaceutical drug primarily used to treat cystic acne.It was developed to be used as a chemotherapy medication for the treatment of brain ca ......by BOC Sciences
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. ......by Selleck Chemicals LLC
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Off-white to orange Solid EBNumber:EB000022650

Storage condition

Solubility

DMSO 60 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 60 mg/mL (199.7 mM); Ethanol1 mg/mL warming (3.32 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target RAR/RXR
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Isotretinoin - Launched
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Safety Data of Isotretinoin

Hazard Symbols : T
Risk Statements : R36/37/38;R61
Safety Statements : S26;S37/39;S45;S53
RTECS : VH6440000
WGKGermany : 3
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 4759-48-2

Name CAS No Formula MW

Recommended Compounds in RAR/RXR

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 196996 958295-17-5 C24H20BrNO5 482.32
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Acitretin 55079-83-9 C21H26O3 326.43
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Magnolol 528-43-8 C18H18O2 266.33
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
(R)-Flurbiprofen 51543-40-9 C15H13FO2 244.2609
Tamibarotene 94497-51-5 C22H25NO3 351.44
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Isotretinoin

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