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543906-09-8 (Mavoglurant)

1

Identification

Mavoglurant Mavoglurant
Name Mavoglurant
Formula C19H23NO3
MW 313.39
CAS No. 543906-09-8
EINECS
Smiles CC1=CC(C#C[[email protected]]2(O)CCC[[email protected]]3([H])[[email protected]@]2([H])CCN3C(OC)=O)=CC=C1
Synonyms AFQ 056; (3aR,4S,7aR)-methyl 4-hydroxy-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate
InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1
2

Introduction

Background Information

Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist (IC50=30 nM), as a a selective non-competitive antagonist. ......by BOC Sciences
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000022530

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Mavoglurant Novartis Pharmaceuticals Fragile X Syndrome 2011/8/31 2015/9/1 Phase 3 Clinical
Mavoglurant Novartis Pharmaceuticals Dyskinesias Parkinson Disease Movement Disorders Parkinsonian Disorders Anti-Dyskinesia Agents 2011/12/1 2014/12/1 Phase 2 Clinical
Mavoglurant Novartis Pharmaceuticals Patient Diagnosed With OCD and Resistant to SSRI Treatment (Failed SSRI Over 12 Weeks at Appropriate Doses). 2013/3/14 2015/4/1 Phase 2 Clinical
Mavoglurant - Phase 3
7

Safety Data of Mavoglurant

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD420();10mg/USD540() USA
DC Chemicals 10mg/USD450();25mg/USD700();100mg/USD1800() China
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD540() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD540() China
10

Related Products

Other Forms of 543906-09-8

Name CAS No Formula MW
Mavoglurant (racemate) 1636881-61-2 C19H23NO3 313.39

Recommended Compounds in mGluR

Name CAS No Formula MW
Topiramate 97240-79-4 C12H21NO8S 339.36
L-Glutamine 56-85-9 C5H10N2O3 146.14
JNJ-40411813 1127498-03-6 C20H25ClN2O 344.88
JNJ-42153605 1254977-87-1 C22H23F3N4 400.44
VU 0364439 1246086-78-1 C18H13Cl2N3O3S 422.29
RG7090 802906-73-6 C18H13ClFN3 325.7673
CTEP 871362-31-1 C19H13ClF3N3O 391.77
MPEP 96206-92-7 C14H11N 193.24
VU 0357121 433967-28-3 C17H17F2NO2 305.32
LY404039 635318-11-5 C7H9NO6S 235.21
Dipraglurant 872363-17-2 C16H12FN3 265.29
CPPHA 693288-97-0 C22H15ClN2O4 406.82
MPEP (Hydrochloride) 219911-35-0 C14H12ClN 229.7
TCN238 125404-04-8 C12H11N3 197.2358
VU0361737 1161205-04-4 C13H11ClN2O2 262.69
MTEP (hydrochloride) 1186195-60-7 C11H9ClN2S 236.72
ADX-47273 851881-60-2 C20H17F2N3O2 369.3647
LY2979165 1311385-32-6 C13H22N6O6S 390.41538
LY341495 201943-63-7 C20H19NO5 353.37
L-Glutamic acid monosodium salt 142-47-2 C5H8NNaO4 169.11108928

Recommended Compounds in Same Indication

Name CAS No Formula MW
(R)-Baclofen 69308-37-8 C10H12ClNO2 213.66
Ampalex 154235-83-3 C14H15N3O 241.29
11

Route of Synthesis

12

References

13

More Information

Mavoglurant

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