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1169562-71-3 (XL413 (hydrochloride))

1

Identification

XL413 (hydrochloride) XL413 (hydrochloride)
Name XL413 (hydrochloride)
Formula C14H13Cl2N3O2
MW 326.18
CAS No. 1169562-71-3
EINECS
Smiles ClC1=CC=C2C(C(N=C([[email protected]@H]3CCCN3)NC4=O)=C4O2)=C1.[H]Cl
Synonyms XL-413 hydrochloride;XL 413 hydrochloride; (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
InChI InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H/t9-;/m0./s1
2

Introduction

XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases.

Background Information

XL413 inhibits the cell proliferation. XL413 decreases cell viability and elicits the caspase 3/7 activity in Colo-205 cells. XL413 results in modified S phase progression that subsequently leads to apoptotic cell death. XL413, at the 3 mg/kg dose, causes 70% inhibition of phosphorylated MCM2, and causes significant tumor growth regression at the 100 mg/kg dose. ......by AbMole BioScience
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. ......by AdooQ BioScience, LLC
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the ......by BOC Sciences
XL413 hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM. ......by MedChemexpress Co., Ltd.
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication. ......by MedKoo Biosciences, Inc.
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2. ......by Selleck Chemicals LLC
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000022526

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Solid tumor Hematological neoplasm
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
XL413 (hydrochloride) Bristol-Myers Squibb Co Solid tumor 2009/5/31 2010/8/1 Phase 2 Clinical
XL413 (hydrochloride) Bristol-Myers Squibb Co Hematological neoplasm 2009/3/31 2009/11/30 Phase 2 Clinical
XL413 (hydrochloride) - Discontinued
XL413 (hydrochloride) - No Development Reported
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Safety Data of XL413 (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
A2Z Chemical 50mg/USD590() USA
AbMole BioScience 10mg/USD200(Out of stock) USA
AdooQ BioScience, LLC 5mg/USD120() USA
Affix Scientific 10mg/USD320() USA
Apexbio Technology LLC 5mg/USD136(In stock);50mg/USD587(In stock) USA
Ark Pharm, Inc. USA
Axon Medchem BV 5mg/USD144(In Stock) Netherlands
BOC Sciences
BioVision, Inc., 5mg/USD125() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD144();10mg/USD200() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD144();10mg/USD200() USA
MedKoo Biosciences, Inc. 5mg/USD150() USA
Santa Cruz Biotechnology, Inc. 5mg/USD260() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD144();10mg/USD200() China
Target Molecule Corp. 5mg/USD116();100mg/USD857() USA
Tocris Bioscience Inc. 10mg/USD195() USA
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Related Products

Other Forms of 1169562-71-3

Name CAS No Formula MW
XL413 1169558-38-6 C14H12ClN3O2 289.72

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
AZD1152 722543-31-9 C26H31FN7O6P 587.54
PU-H71 873436-91-0 C18H21IN6O2S 512.37
BMS-599626 (Hydrochloride) 873837-23-1 C27H28ClFN8O3 567.01
AT9283 896466-04-9 C19H23N7O2 381.43
KX2-391 897016-82-9 C26H29N3O3 431.53
SNX-2112 908112-43-6 C23H27F3N4O3 464.48
Nordihydroguaiaretic acid 500-38-9 C18H22O4 302.36
Pazopanib (Hydrochloride) 635702-64-6 C21H24ClN7O2S 473.98
RX-3117 865838-26-2 C10H12FN3O4 257.22
OSU-03012 742112-33-0 C26H19F3N4O 460.45
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 569.44
LY2603618 911222-45-2 C18H22BrN5O3 436.3
AT13387 912999-49-6 C24H31N3O3 409.52
Dasatinib (hydrochloride) 854001-07-3 C22H27Cl2N7O2S 524.47
Delanzomib 847499-27-8 C21H28BN3O5 413.28
SU14813 (maleate) 849643-15-8 C27H31FN4O8 558.56
MEK162 606143-89-9 C17H15BrF2N4O3 441.23
AT7519 844442-38-2 C16H17Cl2N5O2 382.24
PCI-24781 783355-60-2 C21H23N3O5 397.42
Plinabulin 714272-27-2 C19H20N4O2 336.39
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Route of Synthesis

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References

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More Information

XL413 (hydrochloride)

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