• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

719277-26-6 (TG003)

1

Identification

TG003 TG003
Name TG003
Formula C13H15NO2S
MW 249.33
CAS No. 719277-26-6
EINECS
Smiles CC(/C=C1SC2=CC=C(OC)C=C2N1CC)=O
Synonyms TG 003;TG-003; (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
InChI InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
2

Introduction

TG003 is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2(IC50= 200 nM). IC50 value: 20 nM (Clk1); 15 nM(Clk4); 200 nM (CIk2) [1] Target: CIk1/CIk4 TG003 showed the most potent effect on Clk1/Sty and Clk4 (IC50, 15–20 nM) and lesser on Clk2 (200 nM).

Background Information

TG003 is a potent, specific, reversible, and ATP competitive inhibitor of Cdc2 like kinase(Clk).- ......by AdooQ BioScience, LLC
TG003 is a potent, ATP-competitive inhibitor of Clk-family kinases. TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. TG003 also suppressed serine/arginine-rich protein phosphorylat ......by BOC Sciences
Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC₅₀ = 20 nM, 200 nM, >10 µM, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively). Recently, it has been shown that TG003 promotes the skipping of exon 31 in the endogenous dystrophin gene in a dose-dependent manner and increases the production of the dystrophin protein. ......by BioVision, Inc.,
TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively. ......by MedChemexpress Co., Ltd.
TG003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 20, 200 and 15 nM for mClk1, 2 and 4 respectively and >10 μ M for mClk3). . TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. TG003 also suppressed serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells. Consistently, administration of TG003 rescued the embryonic defects induced by excessive Clk activity in Xenopus. ......by MedKoo Biosciences, Inc.
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. ......by Selleck Chemicals LLC
Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000019215

Storage condition

Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TG003 - Not Found
TG003 - No Development Reported
7

Safety Data of TG003

Hazard Symbols : Xi
Risk Statements : 36/37/38
Safety Statements : 26-36
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Abcam 5mg/USD115() USA
AdooQ BioScience, LLC 10mg/USD100() USA
Ark Pharm, Inc. USA
Axon Medchem BV 10mg/USD138(In Stock);50mg/USD498(In Stock) Netherlands
BOC Sciences
BioVision, Inc., 5mg/USD100() USA
CHEMSCENE, LLC 10mg/USD180();50mg/USD540() USA
Cayman Chemical Company 1mg/USD18() USA
MedChemexpress Co., Ltd. 10mg/USD180();50mg/USD540() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 5mg/USD122(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD180();50mg/USD540() China
Tocris Bioscience Inc. 10mg/USD185() USA
Toronto Research Chemicals Inc. 5mg/USD90() Canada
10

Related Products

Other Forms of 719277-26-6

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

TG003

Tags: buy 719277-26-6 IC50 | 719277-26-6 price | 719277-26-6 cost | 719277-26-6 solubility | 719277-26-6 purchase | 719277-26-6 manufacturer | 719277-26-6 research buy | 719277-26-6 order | 719277-26-6 MSDS | 719277-26-6 chemical structure | 719277-26-6 Storage condition | 719277-26-6 molecular weight | 719277-26-6 mw | 719277-26-6 datasheet | 719277-26-6 supplier | 719277-26-6 cell line | 719277-26-6 NMR | 719277-26-6 MS | 719277-26-6 IR | 719277-26-6 solubility | 719277-26-6 Safe information | 719277-26-6 Qc and Spectral Information | 719277-26-6 Clinical Information | 719277-26-6 Clinical Trial | 719277-26-6 Route of Synthesis | 719277-26-6 storage condition | 719277-26-6 diseases and conditions | 719277-26-6 flash point | 719277-26-6 boiling point | 719277-26-6 melting point | 719277-26-6 storage condition | 719277-26-6 brand