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367514-88-3 (Lurasidone (Hydrochloride))

1

Identification

Lurasidone (Hydrochloride) Lurasidone (Hydrochloride)
Name Lurasidone (Hydrochloride)
Formula C28H37ClN4O2S
MW 529.14
CAS No. 367514-88-3
EINECS
Smiles O=C([[email protected]]([[email protected]]1CC[[email protected]@H]2C1)[[email protected]]2C3=O)N3C[[email protected]@H]4CCCC[[email protected]]4CN(CC5)CCN5C6=NSC7=CC=CC=C76.Cl
Synonyms SM 13496;SM13496;SM-13496; (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride
InChI InChI=1S/C28H36N4O2S.ClH/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26;/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2;1H/t18-,19+,20-,21-,24+,25-;/m0./s1
2

Introduction

Lurasidone Hcl (SM 13496 Hcl) is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. IC50 Value: 1.68 nM(Dopamine D2); 2.03 nM(5-HT2A); 0.495 nM(5-HT7); 6.75 nM(5-HT1A); 10.8 nM (noradrenaline α2C) Target: 5-HT Receptor; Dopamine Receptor in vitro: Lurasidone antagonizes dopamine-stimulated [35S]GTPγS binding at human dopamine D2L receptor in a concentration-dependent manner with a KB value of 2.8 nM.

Background Information

Also known as SM-13496 and is an atypical antipsychotic drug ......by AOBIOUS INC
Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. ......by BOC Sciences
Lurasidone is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM. ......by MedChemexpress Co., Ltd.
Lurasidone HCl, also known as SM-13496, is an atypical antipsychotic drug. In the USA since 2013, it is also approved for the treatment of depressive episodes associated with bipolar I disorder as well as bipolar II disorder in adults when used alone or in combination with lithium, valproate, or lamotrigine. Lurasidone may be useful for treating the cognitive and memory deficits seen in schizophrenia. Lurasidone has activity at several serotonin receptors that are involved in learning and memory. ......by MedKoo Biosciences, Inc.
Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. ......by Selleck Chemicals LLC
Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000018898

Storage condition

Solubility

DMSO 1 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 1 mg/mL (1.88 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lurasidone (Hydrochloride) Massachusetts General Hospital Mania 2013/10/31 2018/7/31 Phase 4 Clinical
Lurasidone (Hydrochloride) Northwestern University Schizophrenia 2011/10/31 2014/4/1 Phase 4 Clinical
Lurasidone (Hydrochloride) Dainippon Sumitomo Pharma Co Ltd Bipolar I disorder 2013/11/30 2017/9/30 Phase 3 Clinical
Lurasidone (Hydrochloride) Dainippon Sumitomo Pharma Co Ltd Bipolar I disorder 2013/11/30 2016/9/30 Phase 3 Clinical
Lurasidone (Hydrochloride) University of California Irvine Schizophrenia 2008/12/31 2013/10/31 Phase 3 Clinical
Lurasidone (Hydrochloride) - Launched
7

Safety Data of Lurasidone (Hydrochloride)

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AbMole BioScience 5mg/USD140(Out of stock) USA
Apexbio Technology LLC USA
BOC Sciences 5g/USD189(In stock)
Beijing Mesochem Technology Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD72();50mg/USD120() USA
Carbosynth Limited 1g/USD1400()
Clearsynth Labs Limited 25mg/USD100() India
J&K Scientific Ltd. 1mg/RMB770(ship in 3-5 weeks) China
Lanzhou Boc Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD72();50mg/USD120() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 5mg/USD350() USA
Selleck Chemicals LLC 5mg/USD170(In stock) USA
Shanghai Famo Bio-chemical Technology Company Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD72();50mg/USD120() China
Shanghai Sinoflychem Co., Ltd. China
Sigma-Aldrich, Inc. 1mL/USD132() USA
Target Molecule Corp. 5mg/USD39();25mg/USD72();100mg/USD158() USA
Thode Laboratories 25mg/USD85(In stock) Canada
Toronto Research Chemicals Inc. 1mg/USD55();5mg/USD175();25mg/USD350();100mg/USD700() Canada
ZHIYU Biotechnology Co., Ltd. China
10

Related Products

Other Forms of 367514-88-3

Name CAS No Formula MW
Lurasidone 367514-87-2 C28H36N4O2S 492.68

Recommended Compounds in Dopamine Receptor 5-HT Receptor

Name CAS No Formula MW
SKF 38393 (hydrobromide) 20012-10-6 C16H18BrNO2 336.22
Ropinirole (hydrochloride) 91374-20-8 C16H25ClN2O 296.84
Fenoldopam 67227-56-9 C16H16ClNO3 305.76
Pergolide (mesylate) 66104-23-2 C20H30N2O3S2 410.59
Trifluoperazine (dihydrochloride) 440-17-5 C21H26Cl2F3N3S 480.42
Clomipramine (hydrochloride) 17321-77-6 C19H24Cl2N2 351.31
Dopamine (hydrochloride) 62-31-7 C8H12ClNO2 189.64
Domperidone 57808-66-9 C22H24ClN5O2 425.91
Pramipexole 104632-26-0 C10H17N3S 211.33
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Chlorprothixene 113-59-7 C18H18ClNS 315.86
Haloperidol (hydrochloride) 1511-16-6 C21H24Cl2FNO2 412.33
Risperidone (mesylate) 666179-96-0 C24H31FN4O5S 506.59
Risperidone (hydrochloride) 666179-74-4 C23H28ClFN4O2 446.95
Iloperidone (hydrochloride) 1299470-39-5 C24H28ClFN2O4 462.94
Ziprasidone 146939-27-7 C21H21ClN4OS 412.9356
Brexpiprazole 913611-97-9 C25H27N3O2S 433.57
Amisulpride (hydrochloride) 81342-13-4 C17H28ClN3O4S 405.94
L-DOPA 59-92-7 C9H11NO4 197.19
Cariprazine (hydrochloride) 1083076-69-0 C21H33Cl3N4O 463.87

Recommended Compounds in Same Indication

Name CAS No Formula MW
Rifabutin 72559-06-9 C46H62N4O11 847.0
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
PF-2545920 898562-94-2 C25H20N4O 392.45
lumateperone (Tosylate) 1187020-80-9 C31H36FN3O4S 565.6987
Lu AE58054 467459-31-0 C20H19F5N2O 398.37
EVP-6124 550999-75-2 C16H17ClN2OS 320.84
Asenapine 65576-45-6 C17H16ClNO 285.77
Adoprazine 222551-17-9 C24H24FN3O2 405.46
Clozapine 5786-21-0 C18H19ClN4 326.82
Bitopertin 845614-11-1 C21H20F7N3O4S 543.46
Bitopertin (R enantiomer) 845614-12-2 C21H20F7N3O4S 543.46
Preladenant 377727-87-2 C25H29N9O3 503.56
Ziprasidone (hydrochloride monohydrate) 138982-67-9 C21H24Cl2N4O2S 467.41
Ziprasidone D8 1126745-58-1 C21H13D8ClN4OS 420.9849
Talnetant 174636-32-9 C25H22N2O2 382.45
Talnetant (hydrochloride) 204519-66-4 C25H23ClN2O2 418.92
TAK-063 1238697-26-1 C23H17FN6O2 428.42
Iloperidone 133454-47-4 C24H27FN2O4 426.48
Tolcapone 134308-13-7 C14H11NO5 273.24
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Route of Synthesis

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References

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More Information

Lurasidone (Hydrochloride)

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