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69308-37-8 ((R)-Baclofen)

1

Identification

(R)-Baclofen (R)-Baclofen
Name (R)-Baclofen
Formula C10H12ClNO2
MW 213.66
CAS No. 69308-37-8
EINECS
Smiles ClC1=CC=C([[email protected]](CC(O)=O)([H])CN)C=C1
Synonyms STX 209;STX-209;STX209; (R)-4-amino-3-(4-chlorophenyl)butanoic acid
InChI InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1
2

Introduction

(R)-Baclofen(STX209) is a selective GABAB receptor agonist.

Background Information

(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. ......by Selleck Chemicals LLC
(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018144

Storage condition

Solubility

DMSO >10 mM Water >25 mM by MedChemexpress Co., Ltd.
(25°C) * In vitro Water 8 mg/mL (37.44 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
(R)-Baclofen Seaside Therapeutics Inc Autism 2011/11/30 2013/7/1 Phase 3 Clinical
(R)-Baclofen Seaside Therapeutics Inc Fragile X syndrome 2011/11/30 2013/7/1 Phase 3 Clinical
(R)-Baclofen Seaside Therapeutics Inc Fragile X syndrome 2011/6/30 2013/8/31 Phase 3 Clinical
(R)-Baclofen Seaside Therapeutics Inc Fragile X syndrome 2011/5/31 2013/2/28 Phase 3 Clinical
(R)-Baclofen Seaside Therapeutics Inc Autism 2011/5/31 2012/9/30 Phase 2 Clinical
(R)-Baclofen - Suspended
(R)-Baclofen - No Development Reported
7

Safety Data of (R)-Baclofen

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 50mg/USD120(Out of stock) USA
Abcam 10mg/USD59() USA
CHEMSCENE, LLC 10mg/USD60();50mg/USD216() USA
EMD Millipore 10mg/USD74() USA
Hello Bio Inc. 10mg/USD59() USA
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD216() USA
Santa Cruz Biotechnology, Inc. 10mg/USD50() USA
Selleck Chemicals LLC 10mg/USD97(In stock);50mg/USD310(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD216() China
Target Molecule Corp. 10mg/USD48();50mg/USD116() USA
Tocris Bioscience Inc. 10mg/USD89() USA
10

Related Products

Other Forms of 69308-37-8

Name CAS No Formula MW
(R)-Baclofen (hydrochloride) 63701-55-3 C10H13Cl2NO2 250.12

Recommended Compounds in GABA Receptor

Name CAS No Formula MW
Tiagabine (hydrochloride) 145821-59-6 C20H26ClNO2S2 412.01
alpha-Asarone 2883-98-9 C12H16O3 208.2536
Zopiclone 43200-80-2 C17H17ClN6O3 388.81
Tiagabine (hydrochloride) 145821-59-6 C20H26ClNO2S2 412.0089
Procaine (hydrochloride) 51-05-8 C13H21ClN2O2 272.77
Procaine 59-46-1 C13H20N2O2 236.31
Ginkgolide A 15291-75-5 C20H24O9 408.4
Nefiracetam 77191-36-7 C14H18N2O2 246.3
Primidone 125-33-7 C12H14N2O2 218.25
(R)-Baclofen (hydrochloride) 63701-55-3 C10H13Cl2NO2 250.12
Etomidate (hydrochloride) 53188-20-8 C14H17ClN2O2 280.75
Etomidate 33125-97-2 C14H16N2O2 244.29
(+)-Bicuculline 485-49-4 C20H17NO6 367.35
Zolpidem 82626-48-0 C19H21N3O 307.39
Etifoxine 21715-46-8 C17H17ClN2O 300.78
Etifoxine (hydrochloride) 56776-32-0 C17H18Cl2N2O 337.24
Vigabatrin (Hydrochloride) 1391054-02-6 C6H12ClNO2 165.62
Vigabatrin 68506-86-5 C6H11NO2 129.16
Acamprosate (calcium) 77337-73-6 C10H20CaN2O8S2 400.48
AWD 131-138 188116-07-6 C13H14ClN3O2 279.72

Recommended Compounds in Same Indication

Name CAS No Formula MW
Mavoglurant 543906-09-8 C19H23NO3 313.39
Bumetanide 28395-03-1 C17H20N2O5S 364.42
Ampalex 154235-83-3 C14H15N3O 241.29
Aripiprazole 129722-12-9 C23H27Cl2N3O2 448.39
Donepezil (Hydrochloride) 120011-70-3 C24H30ClNO3 415.95
11

Route of Synthesis

12

References

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More Information

(R)-Baclofen

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