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78281-72-8 (Nepafenac)

1

Identification

Nepafenac Nepafenac
Name Nepafenac
Formula C15H14N2O2
MW 254.28
CAS No. 78281-72-8
EINECS
Smiles O=C(N)CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N
Synonyms AHR 9434;AL 6515;Nevanac;AHR9434;AHR-9434;AL6515;AL-6515; 2-(2-amino-3-benzoylphenyl)acetamide
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
2

Introduction

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac. IC50 value: Target: COX-2 Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

Background Information

Nepafenac is an analgesic selective inhibitor of COX-2. Nepafenac is also a non-steroidal anti-inflammatory with analgesic activity. Nepafenac is used to treat pain and inflammation associated with cataract surgery. ......by AbMole BioScience
Nepafenac is a non-steroidal anti-inflammatory agent. ......by AdooQ BioScience, LLC
An inhibitor of COX-1 and COX-2 ......by BOC Sciences
Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop (0.1% solution. Nepafenac is manufactured by Alcon as Nevanac. It is used to treat pain and inflammation associated with cataract surgery. The usual dose is 1 drop in each affected eye beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period. Its side effects may include decreased visual acuity, a feeling that something is in the eye, increased eye pressure or a sticky sensation, as well as other effects. (Source: http://en.wikipedia.org/wiki/Nepafenac). ......by MedKoo Biosciences, Inc.
A nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 activity; a prodrug of amfenac.Other IndicationApproved ......by ProbeChem
Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery. ......by Selleck Chemicals LLC
Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000018134

Storage condition

Solubility

DMSO Methanol by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 50 mg/mL (196.63 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Nepafenac University of California Macular edema 2013/10/31 2014/10/1 Phase 4 Clinical
Nepafenac Virdi Eye Clinic Pain 2011/5/31 2012/5/31 Phase 4 Clinical
Nepafenac Queen's University Macular edema 2010/2/28 2011/5/31 Phase 4 Clinical
Nepafenac Santa Casa de Misericordia de Santos Ocular pain 2009/3/31 2009/8/31 Phase 4 Clinical
Nepafenac Clinica Oftamologica Zona Sul Cataract 2009/3/31 2011/8/31 Phase 4 Clinical
Nepafenac - Launched
7

Safety Data of Nepafenac

Hazard Symbols : N
Risk Statements : 50/53
Safety Statements : 60-61
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Apichem Chemical Technology Co., Ltd. China
Ark Pharm, Inc. USA
Asia Talent Chemical Limited China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD60();50mg/USD144() USA
Carbosynth Limited 50mg/USD65()
Cayman Chemical Company USA
Combliss Healthcare Industrial Ltd. China
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD144() USA
MedKoo Biosciences, Inc. USA
Nanjing Qihui Pharmtehc Co., Ltd. China
ProbeChem
Santa Cruz Biotechnology, Inc. 10mg/USD240() USA
Selleck Chemicals LLC 10mg/USD120(In stock);25mg/USD210(In stock);100mg/USD770(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD144() China
Sigma-Aldrich, Inc. 10mg/USD55() USA
Suzhou Chemwe, Inc. China
Target Molecule Corp. 2mg/USD38();10mg/USD73();25mg/USD114() USA
Thompson Biological Technology Co., Ltd. China
Tokyo Chemical Industry Co., Ltd. 200mg/USD119() Japan
ZHIYU Biotechnology Co., Ltd. China
Zhejiang Esun Chemical Co., Ltd. China
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Related Products

Other Forms of 78281-72-8

Name CAS No Formula MW
Nepafenac 78281-72-8 C15H14N2O2 254.2839

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37

Recommended Compounds in Same Indication

Name CAS No Formula MW
Tropisetron 89565-68-4 C17H20N2O2 284.35
Capsaicin 404-86-4 C18H27NO3 305.41
Besifloxacin (Hydrochloride) 405165-61-9 C19H22Cl2FN3O3 430.3
Etodolac 41340-25-4 C17H21NO3 287.35
Sufentanil 56030-54-7 C22H30N2O2S 386.55
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
Cebranopadol 863513-91-1 C24H27FN2O 378.48
Gabapentin (hydrochloride) 60142-95-2 C9H18ClNO2 207.7
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Gabapentin 60142-96-3 C9H17NO2 171.24
Sufentanil (citrate) 60561-17-3 C28H38N2O9S 578.67
Celecoxib 169590-42-5 C17H14F3N3O2S 381.37
Atomoxetine (hydrochloride) 82248-59-7 C17H22ClNO 291.82
Diazepam 439-14-5 C16H13ClN2O 284.74
Naloxone (hydrochloride) 357-08-4 C19H22ClNO4 363.84
Etoricoxib 202409-33-4 C18H15ClN2O2S 358.84
Pregabalin 148553-50-8 C8H17NO2 159.23
Rofecoxib 162011-90-7 C17H14O4S 314.36
Tapentadol (hydrochloride) 175591-09-0 C14H24ClNO 257.8
(S)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole 1252673-29-2 C22H26N2O2S 382.519
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Route of Synthesis

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References

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More Information

Nepafenac

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