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22316-47-8 (Clobazam)

1

Identification

Clobazam Clobazam
Name Clobazam
Formula C16H13ClN2O2
MW 300.74
CAS No. 22316-47-8
EINECS
Smiles O=C(C1)N(C)C2=CC=C(Cl)C=C2N(C3=CC=CC=C3)C1=O
Synonyms Clobazepam;Frisium;Frizium;H 4723;HR 376;LM 2717;Mystan;NSC 336279;; 7-chloro-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione
InChI InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
2

Introduction

Clobazam is a 1,5-benzodiazepine, acts as a GABA-A receptor agonist and has anticonvulsant activity.

Background Information

Clobazam is a benzodiazepine derivative. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. Clobazam is discontinued. ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000017857

Storage condition

Solubility

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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Clobazam Pavel Klein|H. Lundbeck A/S|Mid-Atlantic Epilepsy and Sleep Center, LLC Epilepsy 2015/2/1 Phase 4
Clobazam Boston Children’s Hospital|Lundbeck LLC Electrical Status Epilepticus in Sleep 2012/7/1
Clobazam Lundbeck LLC Lennox-Gastaut Syndrome 2005/12/1 Phase 3
Clobazam H. Lundbeck A/S Dravet Syndrome 2015/3/1 Phase 3
Clobazam H. Lundbeck A/S Dravet Syndrome 2015/3/1 Phase 3
Clobazam Lundbeck LLC Epilepsy|Epilepsy, Generalized|Seizures 2005/10/1 Phase 2
Clobazam Lundbeck LLC Epilepsy|Epilepsy, Generalized|Seizures 2007/8/1 Phase 3
Clobazam The Cooper Health System|Lundbeck LLC Epilepsia Partialis Continua|Kojewnikov's Epilepsy|Epilepsy 2014/7/1 Phase 3
Clobazam St. Joseph's Hospital and Medical Center, Phoenix|H. Lundbeck A/S Refractory Epilepsy 2013/2/1 Phase 4
Clobazam University Hospital, Geneva Neuropathic Pain 2010/4/1 Phase 1|Phase 2
Clobazam University Hospital Inselspital, Berne Pain 2009/12/1 Phase 3
Clobazam University Hospital Inselspital, Berne|University of Bern|University of Zurich|Aalborg University Low Back Pain 2010/7/1 Phase 3
Clobazam Assistance Publique - HĂ´pitaux de Paris Epilepsy 2017/6/1
Clobazam Hannover Medical School Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders 2015/1/1 Phase 3
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Safety Data of Clobazam

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
MedKoo Biosciences, Inc. USA
10

Related Products

Other Forms of 22316-47-8

Name CAS No Formula MW

Recommended Compounds in GABA Receptor

Name CAS No Formula MW
Tiagabine (hydrochloride) 145821-59-6 C20H26ClNO2S2 412.01
alpha-Asarone 2883-98-9 C12H16O3 208.2536
Zopiclone 43200-80-2 C17H17ClN6O3 388.81
Tiagabine (hydrochloride) 145821-59-6 C20H26ClNO2S2 412.0089
Procaine (hydrochloride) 51-05-8 C13H21ClN2O2 272.77
Procaine 59-46-1 C13H20N2O2 236.31
Ginkgolide A 15291-75-5 C20H24O9 408.4
Nefiracetam 77191-36-7 C14H18N2O2 246.3
Primidone 125-33-7 C12H14N2O2 218.25
(R)-Baclofen (hydrochloride) 63701-55-3 C10H13Cl2NO2 250.12
Etomidate (hydrochloride) 53188-20-8 C14H17ClN2O2 280.75
Etomidate 33125-97-2 C14H16N2O2 244.29
(+)-Bicuculline 485-49-4 C20H17NO6 367.35
Zolpidem 82626-48-0 C19H21N3O 307.39
Etifoxine 21715-46-8 C17H17ClN2O 300.78
Etifoxine (hydrochloride) 56776-32-0 C17H18Cl2N2O 337.24
(R)-Baclofen 69308-37-8 C10H12ClNO2 213.66
Vigabatrin (Hydrochloride) 1391054-02-6 C6H12ClNO2 165.62
Vigabatrin 68506-86-5 C6H11NO2 129.16
Acamprosate (calcium) 77337-73-6 C10H20CaN2O8S2 400.48

Recommended Compounds in Same Indication

Name CAS No Formula MW
Tropisetron 89565-68-4 C17H20N2O2 284.35
Capsaicin 404-86-4 C18H27NO3 305.41
Etodolac 41340-25-4 C17H21NO3 287.35
Sufentanil 56030-54-7 C22H30N2O2S 386.55
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
Cebranopadol 863513-91-1 C24H27FN2O 378.48
Gabapentin (hydrochloride) 60142-95-2 C9H18ClNO2 207.7
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Gabapentin 60142-96-3 C9H17NO2 171.24
Sufentanil (citrate) 60561-17-3 C28H38N2O9S 578.67
Nepafenac 78281-72-8 C15H14N2O2 254.28
Vigabatrin 68506-86-5 C6H11NO2 129.16
Celecoxib 169590-42-5 C17H14F3N3O2S 381.37
Atomoxetine (hydrochloride) 82248-59-7 C17H22ClNO 291.82
VX-765 273404-37-8 C24H33ClN4O6 509.0
Diazepam 439-14-5 C16H13ClN2O 284.74
Naloxone (hydrochloride) 357-08-4 C19H22ClNO4 363.84
Retigabine 150812-12-7 C16H18FN3O2 303.33
Etoricoxib 202409-33-4 C18H15ClN2O2S 358.84
Nonivamide 2444-46-4 C17H27NO3 293.4
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Route of Synthesis

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References

Protocol Reference

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More Information

Clobazam

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