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212844-54-7 (Purvalanol B)

1

Identification

Purvalanol B Purvalanol B
Name Purvalanol B
Formula C20H25ClN6O3
MW 432.9
CAS No. 212844-54-7
EINECS
Smiles O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[[email protected]@H](CO)C(C)C)=N2)C=C1Cl
Synonyms NG 95;NG95;NG-95; (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid
InChI InChI=1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
2

Introduction

Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

Background Information

A cyclin-dependent kinase inhibitor ......by AOBIOUS INC
Purvalanol B is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.Purvalanol B is Selective over a range of other protein kinases (IC50 > 10,000 nM).It Shown to have antiproliferative properties, mediated by p42/p44 MAPK. Purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases . ......by AbMole BioScience
Purvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). ......by AdooQ BioScience, LLC
Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor. ......by BOC Sciences
Purvalanol B, also known as NG 95, is a potent and selective CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively). ......by MedKoo Biosciences, Inc.
A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2. ......by ProbeChem
Cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000016488

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Purvalanol B - Not Found
Purvalanol B - No Development Reported
7

Safety Data of Purvalanol B

WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AOBIOUS INC USA
AbMole BioScience USA
Abcam 10mg/USD149() USA
Adipogen Corporation USA
AdooQ BioScience, LLC 10mg/USD120() USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD144();50mg/USD540() USA
Cayman Chemical Company USA
DC Chemicals 100mg/USD500(In stock) China
MedChemexpress Co., Ltd. 5mg/USD84();10mg/USD144() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Santa Cruz Biotechnology, Inc. 10mg/USD195() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD84();10mg/USD144() China
Sigma-Aldrich, Inc. 1mg/USD68() USA
Synkinase USA
Tocris Bioscience Inc. 10mg/USD205() USA
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Related Products

Other Forms of 212844-54-7

Name CAS No Formula MW
Purvalanol A 212844-53-6 C19H25ClN6O 388.89

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Purvalanol B

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