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427-51-0 (Cyproterone (acetate))

1

Identification

Cyproterone (acetate) Cyproterone (acetate)
Name Cyproterone (acetate)
Formula
MW 0.0
CAS No. 427-51-0
EINECS 207-048-3
Smiles
Synonyms 6-Chloro-1b,2b-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate; Androcur;
InChI
2

Introduction

Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.

Background Information

Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity. ......by BOC Sciences
Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. ......by Selleck Chemicals LLC
An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Castrate male SD rat
Dosage 0.2 mg /kg/day
Formulation Ethanol
Administration Administered via s.c.
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000016478

Storage condition

Solubility

DMSO 80 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 83 mg/mL (199.06 mM); Ethanol10 mg/mL (23.98 mM); Water<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 8020 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Others
Target Androgen Receptor
Research Area Endocrinology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Cyproterone (acetate) - Launched
7

Safety Data of Cyproterone (acetate)

Hazard Symbols : Xn
Risk Statements : R20/21/22;R40
Safety Statements : S26;S36
RTECS : GZ2230000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 250mg/USD78();500mg/USD144() USA
Cayman Chemical Company 100mg/USD35() USA
Changzhou Hangyu Pharmaceutical Technology Co., Ltd. China
Dimysh ( ShangHai ) Trading Co., Ltd. China
Hubei Gedian Humanwell Pharmaceutical Co., Ltd. China
Hunan Huacheng Pharmaceutical Co., Ltd. China
Jiangxi Hongyuan Pharmaceutical Raw Material Co., Ltd. China
MedChemexpress Co., Ltd. 250mg/USD78();500mg/USD144() USA
Santa Cruz Biotechnology, Inc. 100mg/USD60() USA
Selleck Chemicals LLC 100mg/USD40(In stock);10mM/1mLIn DMSO/USD50(In stock);250mg/USD90(In stock) USA
Shanghai Desano Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 250mg/USD78();500mg/USD144() China
Shaoyang Kerey Chemicals Co., Ltd. China
Sigma-Aldrich, Inc. 250mg/USD206() USA
Target Molecule Corp. 10mg/USD20();50mg/USD75();100mg/USD132();250mg/USD218() USA
Tokyo Chemical Industry Co., Ltd. 200mg/USD98() Japan
Zhejiang Materials Industry Chemical Group Co., Ltd. China
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. China
Zhijiang Guanghong Amino Acid Co., Ltd CHINA
10

Related Products

Other Forms of 427-51-0

Name CAS No Formula MW
Cyproterone 2098-66-0 C24H29ClO4 416.94

Recommended Compounds in Androgen Receptor

Name CAS No Formula MW
Lupeol 545-47-1 C30H50O 426.72
Oxandrolone 53-39-4 C19H30O3 306.44
Testosterone (undecanoate) 5949-44-0 C30H48O3 456.7003
Spironolactone 52-01-7 C24H32O4S 416.57
LGD-4033 1165910-22-4 C14H12F6N2O 338.25
Adrenosterone 382-45-6 C19H24O3 300.39
Triptophenolide 74285-86-2 C20H24O3 312.4
Epiandrosterone 481-29-8 C19H30O2 290.44
3,3'-Diindolylmethane 1968-05-4 C17H14N2 246.31
Boldenone Undecylenate 13103-34-9 C30H44O3 452.67
Testosterone 58-22-0 C19H28O2 288.42
GLPG0492 1215085-92-9 C19H14F3N3O3 389.328
N-desmethyl Enzalutamide 1242137-16-1 C20H14F4N4O2S 450.41
AZD3514 1240299-33-5 C25H32F3N7O2 519.56
ARN-509 956104-40-8 C21H15F4N5O2S 477.43
DHEA 53-43-0 C19H28O2 288.42
RAD140 1182367-47-0 C20H16ClN5O2 393.83
Cortexolone 17 alpha-propionate 19608-29-8 C24H34O5 402.5238
BMS-564929 627530-84-1 C14H12ClN3O3 305.72
MK-0773 606101-58-0 C27H34FN5O2 479.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Cyproterone (acetate)

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