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595-33-5 (Megestrol (Acetate))

1

Identification

Megestrol (Acetate) Megestrol (Acetate)
Name Megestrol (Acetate)
Formula C24H32O4
MW 384.51
CAS No. 595-33-5
EINECS 209-864-5
Smiles C[[email protected]@]12[[email protected]@](OC(C)=O)(C(C)=O)CC[[email protected]@]1([H])[[email protected]@](C=C3C)([H])[[email protected]]([[email protected]](CC4)(C)C3=CC4=O)([H])CC2
Synonyms 17alpha-Acetoxy-6-methylpregna-4,6-diene-3,20-dione; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate; (8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
InChI InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1
2

Introduction

Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2. Target: Progesterone Receptor Megestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.

Background Information

Anti-androgenic and antineoplastic agent, activating nuclear progesterone receptors in the reproductive system and causing the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes ......by AOBIOUS INC
Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite. ......by AbMole BioScience
Megestrol Acetate is a progesterone derivative with antineoplastic properties ......by AdooQ BioScience, LLC
Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HepG2. ......by BOC Sciences
Megestrol acetate is a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Also acts as an appetite stimulant. ......by BioVision, Inc.,
Megestrol acetate is the acetate ester of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes. ......by MedKoo Biosciences, Inc.
Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite. ......by Selleck Chemicals LLC
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) ......by Target Molecule Corp.
Synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000016181

Storage condition

Solubility

DMSO 30 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 33 mg/mL (85.82 mM); Ethanol15 mg/mL (39.01 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Autophagy Others
Target Progesterone Receptor Autophagy
Research Area Endocrinology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Megestrol (Acetate) - Launched
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Safety Data of Megestrol (Acetate)

Hazard Symbols : Xn
Risk Statements : R40;R48
Safety Statements : S22;S24/25
RTECS : TU4075000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AbMole BioScience USA
Abcam 250mg/USD55() USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD66();5g/USD202() USA
Carbosynth Limited 5g/USD60()
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 1g/USD66();5g/USD202() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 1g/USD99() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD163(in 1mL DMSO) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD66();5g/USD202() China
Spectrum Chemical Mfg. Corp. 1g/USD76() USA
Target Molecule Corp. 2mg/USD20();10mg/USD75();50mg/USD142() USA
Tocris Bioscience Inc. USA
Tokyo Chemical Industry Co., Ltd. 1g/USD61() Japan
Zhejiang Horde Pharma Co., Ltd CHINA
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. China
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Related Products

Other Forms of 595-33-5

Name CAS No Formula MW
Megestrol 3562-63-8 C22H30O3 342.47

Recommended Compounds in Progesterone Receptor Autophagy

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Drospirenone 67392-87-4 C24H30O3 366.49
Gestodene 60282-87-3 C21H26O2 310.43
Dienogest 65928-58-7 C20H25NO2 311.42
Progesterone 57-83-0 C21H30O2 314.46
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol (diacetate) 297-76-7 C24H32O4 384.5085
Chlormadinone (acetate) 302-22-7 C23H29ClO4 404.927
Gestonorone Capronate 1253-28-7 C26H38O4 414.57752

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Megestrol (Acetate)

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