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83461-56-7 (Mifamurtide)

1

Identification

Mifamurtide Mifamurtide
Name Mifamurtide
Formula C59H109N6O19P
MW 1237.5
CAS No. 83461-56-7
EINECS
Smiles O=P(OC[[email protected]@H](COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)(O)OCCNC([[email protected]](C)NC(CC[[email protected]](C(N)=O)NC([[email protected]](C)NC([[email protected]@H](C)O[[email protected]@H]([[email protected]](O)[[email protected]@H](CO)O1)[[email protected]@H](NC(C)=O)C1O)=O)=O)=O)=O
Synonyms Muramyl tripeptide phosphatidylethanolamine; N-(N-Acetylmuramoyl)-L-alanyl-D-alpha-glutaminyl-N-[(7R)-4-hydroxy-4-oxido-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-trioxa-4-phosphapentacos-1-yl]-L-alaninamid; (2R)-3-(((((5S,10R,13S,16R)-16-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-10-carbamoyl-5,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate
InChI InChI=1S/C59H109N6O19P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-50(69)79-40-46(83-51(70)34-32-30-28-26-24-22-20-18-16-14-12-10-8-2)41-81-85(77,78)80-38-37-61-56(73)42(3)62-49(68)36-35-47(55(60)72)65-57(74)43(4)63-58(75)44(5)82-54-52(64-45(6)67)59(76)84-48(39-66)53(54)71/h42-44,46-48,52-54,59,66,71,76H,7-41H2,1-6H3,(H2,60,72)(H,61,73)(H,62,68)(H,63,75)(H,64,67)(H,65,74)(H,77,78)/t42-,43-,44+,46+,47+,48+,52+,53+,54+,59?/m0/s1
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Introduction

Mifamurtide(CGP19835; MTP-PE) is a drug against osteosarcoma. Target: Others Mifamurtide is an immunomodulator with antitumor effects that appear to be mediated via activation of monocytes and macrophages.

Background Information

Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities ......by AdooQ BioScience, LLC
Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities. It is a derivative of the mycobacterial cell wall component MDP and activates both monocytes and macrophage ......by BOC Sciences
Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities.. Muramyl tripeptide phosphatidylethanolamine (MTP-PE), a derivative of the mycobacterial cell wall component MDP, activates both monocytes and macrophages. Activated macrophages secrete cytokines and induce the recruitment and activation of other immune cells, which may result in indirect tumoricidal effects. Liposomal encapsulation of MTP-PE prolongs its half-life and enhances tissue targeting. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ......by MedKoo Biosciences, Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000016174

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target TRP Channel
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Mifamurtide - Launched
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Safety Data of Mifamurtide

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD101();50mg/USD406() USA
China Jintai Biocompound Company China
MedChemexpress Co., Ltd. 10mg/USD101();50mg/USD406() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 10mg/USD105() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD101();50mg/USD406() China
Sigma-Aldrich, Inc. 10mg/USD111() USA
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Related Products

Other Forms of 83461-56-7

Name CAS No Formula MW

Recommended Compounds in TRP Channel

Name CAS No Formula MW
SN 2 823218-99-1 C17H21NO 255.35
SB 366791 472981-92-3 C16H14ClNO2 287.74
Nonivamide 2444-46-4 C17H27NO3 293.4
Tramadol (hydrochloride) 36282-47-0 C16H26ClNO2 299.84
Probenecid 57-66-9 C13H19NO4S 285.36
SAR7334 (hydrochloride) 1333207-63-8 C21H24Cl3N3O 440.79376
Imperatorin 482-44-0 C16H14O4 270.28
SAR7334 1333210-07-3 C21H22ClN3O 367.87188
Capsazepine 138977-28-3 C19H21ClN2O2S 376.9
Rosiglitazone 122320-73-4 C18H19N3O3S 357.43
D-3263 (hydrochloride) 1008763-54-9 C21H32ClN3O3 409.9501
D-3263 947257-66-1 C21H31N3O3 373.49
Chembridge-5861528 332117-28-9 C19H23N5O3 369.4176
HC-030031 349085-38-7 C18H21N5O3 355.39
ABT-239 460746-46-7 C22H22N2O 330.4229
Icilin 36945-98-9 C16H13N3O4 311.29
AMG 517 659730-32-2 C20H13F3N4O2S 430.4
SB-705498 501951-42-4 C17H16BrF3N4O 429.23
Capsaicin 404-86-4 C18H27NO3 305.41
SKF-96365 (hydrochloride) 130495-35-1 C22H27ClN2O3 402.9144

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Mifamurtide

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