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29110-48-3 (Guanfacine (hydrochloride))

1

Identification

Guanfacine (hydrochloride) Guanfacine (hydrochloride)
Name Guanfacine (hydrochloride)
Formula C9H10Cl3N3O
MW 282.55
CAS No. 29110-48-3
EINECS 249-443-3
Smiles O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl.[H]Cl
Synonyms Guanfacine;Tenex;Intuniv; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride
InChI InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
2

Introduction

Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.

Background Information

Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. ......by AbMole BioScience
Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over ??2B-adrenoceptors. ......by AdooQ BioScience, LLC
Guanfacine HCl is the hydrochloride salt of Guanfacine. Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hyperactivity disorder (ADHD) and hypertension. It lowers both systolic and diastolic blood pressur ......by BOC Sciences
Guanfacine, also known as BS 100-141 and SPD-503, is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension (not to be confused with guaifenesin, an expectorant). It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. Guanfacine is currently approved and marketed in the United States[8] and Europe[9] as Intuniv for the treatment of ADHD in children and adolescents aged 6–18 years. ......by MedKoo Biosciences, Inc.
Guanfacine Hydrochloride is a centrally acting alpha-2 adrenergic agonist with antihypertensive activity. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance. ......by MedKoo Biosciences, Inc.
A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD).HypertensionApproved ......by ProbeChem
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. ......by Selleck Chemicals LLC
A centrally acting antihypertensive agent with specificity towards α2A-adrenoceptor. ......by Target Molecule Corp.
Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000016143

Storage condition

Solubility

DMSO 100 mM Water 100 mM by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Guanfacine (hydrochloride) Jpm Van Stralen Medicine Professional Corporation Attention deficit hyperactivity disorder 2013/10/31 2014/8/31 Phase 4 Clinical
Guanfacine (hydrochloride) Yale University Pervasive child developmental disorder 2011/12/31 2014/3/31 Phase 4 Clinical
Guanfacine (hydrochloride) Shire Pharmaceutical Development Ltd Attention deficit hyperactivity disorder 2009/11/30 2010/10/31 Phase 3 Clinical
Guanfacine (hydrochloride) Shire Pharmaceutical Development Ltd Attention deficit hyperactivity disorder 2006/9/30 2008/1/31 Phase 3 Clinical
Guanfacine (hydrochloride) Shire plc Attention deficit hyperactivity disorder 2012/3/31 2015/11/30 Phase 3 Clinical
Guanfacine (hydrochloride) - Launched
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Safety Data of Guanfacine (hydrochloride)

WGKGermany : 3
8

Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD66();50mg/USD192() USA
CacheSyn Inc. Canada
Carbosynth Limited 10mg/USD67()
Cayman Chemical Company USA
Clearsynth Labs Limited 25mg/USD200() India
Combliss Healthcare Industrial Ltd. China
MedChemexpress Co., Ltd. 10mg/USD66();50mg/USD192() USA
MedKoo Biosciences, Inc. USA
MedKoo Biosciences, Inc. USA
ProbeChem
Santa Cruz Biotechnology, Inc. 10mg/USD65() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD66();50mg/USD192() China
Target Molecule Corp. 5mg/USD99();10mg/USD136();50mg/USD176();100mg/USD308() USA
Tocris Bioscience Inc. 10mg/USD75() USA
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Related Products

Other Forms of 29110-48-3

Name CAS No Formula MW
Guanfacine 29110-47-2 C9H9Cl2N3O 246.09

Recommended Compounds in Adrenergic Receptor

Name CAS No Formula MW
Tolazoline 59-98-3 C10H12N2 160.22
Synephrine (hydrochloride) 5985-28-4 C9H14ClNO2 203.67
(R)-(-)-Phenylephrine 59-42-7 C9H13NO2 167.205
Nicergoline 27848-84-6 C24H26BrN3O3 484.39
Tamsulosin (hydrochloride) 106463-17-6 C20H29ClN2O5S 444.97
Tamsulosin 106133-20-4 C20H28N2O5S 408.51
UK 14,304 59803-98-4 C11H10BrN5 292.13
Guanfacine 29110-47-2 C9H9Cl2N3O 246.09
Propranolol (hydrochloride) 318-98-9 C16H22ClNO2 295.8
Guanabenz (Acetate) 23256-50-0 C10H12Cl2N4O2 291.13
Tetrahydrozoline (hydrochloride) 522-48-5 C13H17ClN2 236.74
Octopamine (hydrochloride) 770-05-8 C8H12ClNO2 189.64
Betaxolol (hydrochloride) 63659-19-8 C18H30ClNO3 343.89
Indacaterol (maleate) 753498-25-8 C28H32N2O7 508.56
Medetomidine (hydrochloride) 86347-15-1 C13H17ClN2 236.74
Norepinephrine (bitartrate monohydrate) 108341-18-0 C12H19NO10 337.28
Norepinephrine (hydrochloride) 329-56-6 C8H12ClNO3 205.64
Xylometazoline (hydrochloride) 1218-35-5 C16H25ClN2 280.84
(R)-(-)-Phenylephrine (hydrochloride) 61-76-7 C9H14ClNO2 203.67
Isoprenaline (hydrochloride) 51-30-9 C11H18ClNO3 247.72

Recommended Compounds in Same Indication

Name CAS No Formula MW
Atomoxetine (hydrochloride) 82248-59-7 C17H22ClNO 291.82
GTS-21 148372-04-7 C19H20N2O2 308.37
Naltrexone 16590-41-3 C20H23NO4 341.4
Bavisant (dihydrochloride hydrate) 1103522-80-0 C19H31Cl2N3O3 420.37
Naltrexone (Hydrochloride) 16676-29-2 C20H24ClNO4 377.86
GTS-21 (dihydrochloride) 156223-05-1 C19H22Cl2N2O2 381.3
Bavisant 929622-08-2 C19H27N3O2 329.44
Bavisant (dihydrochloride) 929622-09-3 C19H29Cl2N3O2 402.36
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Route of Synthesis

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References

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More Information

Guanfacine (hydrochloride)

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