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83919-23-7 (Mometasone furoate)

1

Identification

Mometasone furoate Mometasone furoate
Name Mometasone furoate
Formula C32H32Cl2O8
MW 615.5
CAS No. 83919-23-7
EINECS
Smiles C[[email protected]@]12[[email protected]](OC(C3=CC=CO3)=O)([[email protected]@H](C[[email protected]]1([[email protected]@]4(CCC5=CC(C=C[[email protected]@]5(C4([[email protected]@H](OC(C6=CC=CO6)=O)C2)Cl)C)=O)[H])[H])C)C(CCl)=O
Synonyms 9-Chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate; (8S,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-11,17-diyl bis(furan-2-carboxylate)
InChI InChI=1S/C32H32Cl2O8/c1-18-14-22-21-9-8-19-15-20(35)10-11-29(19,2)31(21,34)26(41-27(37)23-6-4-12-39-23)16-30(22,3)32(18,25(36)17-33)42-28(38)24-7-5-13-40-24/h4-7,10-13,15,18,21-22,26H,8-9,14,16-17H2,1-3H3/t18-,21+,22+,26+,29+,30+,31?,32+/m1/s1
2

Introduction

Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. IC50 value: Target: glucocorticosteroid receptor Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma [1].

Background Information

Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. ......by BOC Sciences
Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways. ......by Selleck Chemicals LLC
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000015728

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 6 mg/mL (11.5 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Mometasone furoate - Launched
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Safety Data of Mometasone furoate

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Abcam 50mg/USD105() USA
BOC Sciences 5g/USD499(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD60();100mg/USD96() USA
Carbosynth Limited 5mg/USD24()
Clearsynth Labs Limited 25mg/USD150() India
Hangzhou Bm Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD96() USA
Pure Chemistry Scientific Inc. 1g/USD46(In stock) USA
Santa Cruz Biotechnology, Inc. 10mg/USD100() USA
Selleck Chemicals LLC 50mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);10mM(in 1mL DMSO)/USD113(in 1mL DMSO) USA
Shandong Taihua Bio. & Tech. Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD96() China
Sigma-Aldrich, Inc. 5mg/USD56() USA
Spectrum Chemical Mfg. Corp. 500g/USD10833() USA
Target Molecule Corp. 2mg/USD28();10mg/USD69();50mg/USD165() USA
Tocris Bioscience Inc. 50mg/USD109() USA
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. China
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Related Products

Other Forms of 83919-23-7

Name CAS No Formula MW

Recommended Compounds in Glucocorticoid Receptor

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Prednisolone (disodium phosphate) 125-02-0 C21H27Na2O8P 484.39
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Fluocinolone (Acetonide) 67-73-2 C24H30F2O6 452.49
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Dexamethasone (acetate) 1177-87-3 C24H31FO6 434.5
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
Cortisone 53-06-5 C21H28O5 360.44
AL 082D06 256925-03-8 C23H24ClN3O2 409.91
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Mometasone furoate

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