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827022-32-2 (Palbociclib (hydrochloride))

1

Identification

Palbociclib (hydrochloride) Palbociclib (hydrochloride)
Name Palbociclib (hydrochloride)
Formula C24H30ClN7O2
MW 483.99
CAS No. 827022-32-2
EINECS
Smiles O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.Cl
Synonyms PD-0332991 hydrochloride;PD0332991 hydrochloride;PD 0332991 hydrochloride; 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
InChI InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H
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Introduction

Palbociclib Hcl(PD-0332991) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

Background Information

Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kin ......by BOC Sciences
This research compound is the hydrochloride salt form of palbociclib; please see the free base form of palbociclib, Cat. No. [P-7744], Palbociclib, Free Base, for further technical information about both of these research compounds. Two other forms of palbociclib are also available, Cat. No. [P-7766], Palbociclib, Isethionate Salt and Cat. No. [P-7722], Palbociclib, Dihydrochloride Salt. This palbociclib product is the hydrochloride salt, whose CAS number is given above. The CAS number of the free base form is 571190-30-2, the CAS number of the 1:1.8 hydrochloride salt form is 571189-11-2, the CAS number of the isethionate salt form is 827022-33-3, and the CAS number of the dihydrochloride salt form has not been reported as of October 30, 2014. ......by LC Laboratoies
Palbociclib hydrochloride is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. ......by MedChemexpress Co., Ltd.
Shelf life: >2 years if stored properly Drug formulation: This drug may be formulated in DMSO ......by MedKoo Biosciences, Inc.
PD0332991 is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3. ......by Selleck Chemicals LLC
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000015650

Storage condition

4°C by MedChemexpress Co., Ltd.
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

H2O: 30 mg/mL, DMSO: 3 mg/mL (warmed) by CHEMSCENE, LLC
H2O: 30 mg/mL, DMSO: 3 mg/mL (warmed) by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
DMSO 3 mg/mL (6 mM) ; Water 30 mg/mL (61 mM) ; Ethanol <1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Acute leukemia
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Palbociclib (hydrochloride) Sidney Kimmel Comprehensive Cancer Center Acute leukemia 2012/9/30 2013/4/30 Phase 1 Clinical
Palbociclib (hydrochloride) - Phase 3 Clinical
Palbociclib (hydrochloride) - Launched
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Safety Data of Palbociclib (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 5mg/USD70(In Stock) USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD84() USA
Cayman Chemical Company 1mg/USD25() USA
DC Chemicals 100mg/USD200(In Stock) China
EMD Millipore 5mg/USD99() USA
LC Laboratoies 10mg/USD47(In stock);25mg/USD64(In stock);50mg/USD87(In stock);100mg/USD139(In stock);200mg/USD235(In stock);500mg/USD484(In stock);1g/USD792(In stock);2g/USD1384(In stock) USA
Lancrix Chemicals. 50mg/USD198();200mg/USD558() China
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD84() USA
MedKoo Biosciences, Inc. 100mg/USD120() USA
Santa Cruz Biotechnology, Inc. 5mg/USD120() USA
Selleck Chemicals LLC 5mg/USD110(In stock);10mg/USD170(In stock);10mM/1mLIn DMSO/USD220(In stock);50mg/USD570(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD84() China
Shanghai Sun-shine Chemical Technology Co., Ltd. China
Target Molecule Corp. 5mg/USD68();10mg/USD89();25mg/USD158();50mg/USD290() USA
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Related Products

Other Forms of 827022-32-2

Name CAS No Formula MW
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
Palbociclib 571190-30-2 C24H29N7O2 447.53

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
AT9283 896466-04-9 C19H23N7O2 381.43
OTX-015 202590-98-5 C25H22ClN5O2S 491.99
AVN-944 297730-17-7 C25H27N5O5 477.51
Lurbinectedin 497871-47-3 C41H44N4O10S 784.87
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Route of Synthesis

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References

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More Information

Palbociclib (hydrochloride)

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