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144675-97-8 (Pixantrone (dimaleate))

1

Identification

Pixantrone (dimaleate) Pixantrone (dimaleate)
Name Pixantrone (dimaleate)
Formula C21H23N5O6
MW 441.44
CAS No. 144675-97-8
EINECS
Smiles O=C1c2c(NCCN)ccc(NCCN)c2C(c3c1ccnc3)=O.O=C(/C=CC(O)=O)O
Synonyms 6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione (2Z)-2-butenedioate (1:2); 6,9-bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione maleate
InChI InChI=1S/C17H19N5O2.C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
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Introduction

Background Information

Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tum ......by BOC Sciences
Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. ......by MedChemexpress Co., Ltd.
Shelf life: >2 years if stored properly Drug formulation: ......by MedKoo Biosciences, Inc.
Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Brown to nigger-brown Solid EBNumber:EB000015636

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

Water 15 mg/ml by CHEMSCENE, LLC
Water 15 mg/ml by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target Topoisomerase
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pixantrone (dimaleate) - Launched
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Safety Data of Pixantrone (dimaleate)

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
BioVision, Inc., 5mg/USD80() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD86();10mg/USD144() USA
China Jintai Biocompound Company China
Clearsynth Labs Limited 25mg/USD200() India
MedChemexpress Co., Ltd. 5mg/USD86();10mg/USD144() USA
MedKoo Biosciences, Inc. 5mg/USD80() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD86();10mg/USD144() China
Shanghai SPE Chemicals Co., Ltd. China
Sigma-Aldrich, Inc. USA
Target Molecule Corp. 10mg/USD115();50mg/USD240();100mg/USD343() USA
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Related Products

Other Forms of 144675-97-8

Name CAS No Formula MW
Pixantrone (hydrochloride) 175989-38-5 C17H20ClN5O2 361.83
Pixantrone 144510-96-3 C17H19N5O2 325.37

Recommended Compounds in Topoisomerase

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Exatecan (Mesylate) 169869-90-3 C25H26FN3O7S 531.55
Flumequine 42835-25-6 C14H12FNO3 261.25
Nemorubicin 108852-90-0 C32H37NO13 643.64
Amsacrine (hydrochloride) 54301-15-4 C21H20ClN3O3S 429.92
Ellipticine 519-23-3 C17H14N2 246.31
DOXO-EMCH 151038-96-9 C37H42N4O13 750.75
Topotecan (Hydrochloride) 119413-54-6 C23H24ClN3O5 457.91
Topotecan 123948-87-8 C23H23N3O5 421.45
Tirapazamine 27314-97-2 C7H6N4O2 178.15
Teniposide 29767-20-2 C32H32O13S 656.65
TAS-103 174634-08-3 C20H19N3O2 333.38
TAS-103 (dihydrochloride) 174634-09-4 C20H21Cl2N3O2 406.31
Pixantrone 144510-96-3 C17H19N5O2 325.37
Pirarubicin 72496-41-4 C32H37NO12 627.64
SN-38 86639-52-3 C22H20N2O5 392.4
Irinotecan (hydrochloride) 100286-90-6 C33H39ClN4O6 623.14
Exatecan 171335-80-1 C24H22FN3O4 435.45
Etoposide 33419-42-0 C29H32O13 588.56
Epirubicin (hydrochloride) 56390-09-1 C27H30ClNO11 579.98

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Pixantrone (dimaleate)

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