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478-43-3 (Rhein)



Rhein Rhein
Name Rhein
Formula C15H8O6
MW 284.22
CAS No. 478-43-3
EINECS 207-521-4
Smiles O=C(C1=C2C=CC=C1O)C3=C(O)C=C(C(O)=O)C=C3C2=O
Synonyms 4,5-Dihydroxyanthraquinone-2-carboxylic acid; 1,8-Dihydroxy-3-carboxyanthraquinone; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; Rhubarb yellow; Cassic acid; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
InChI InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)


Yellow needles (from methanol) or yellow-brown powder.

Background Information

Rhein is a substance in the anthraquinone group found in rhubarb species like Rheum undulatum or Rheum palmatum or in Cassia reticulata. ......by AdooQ BioScience, LLC
Rhein induces apoptosis in cancer cell lines and inhibits transforming growth factor β-1 induced plasminogen activator inhibitor-1 in endothelial cells. Rhein is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai. The WTK1 cells were treated by rhein of different concentrations (20, 40, 80, 120 μg/ml) and then the comet assay, in vitro micronucleus test and TK gene mutation assay were conducted simultaneously. Rhein treatment significantly improved glucos ......by Affix Scientific
Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. ......by BOC Sciences
Rhein is an anti-inflammatory, anti-osteoarthritic, and anti-cancer agent. ......by MedKoo Biosciences, Inc.
Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. ......by Selleck Chemicals LLC
Rhein is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Extracted from Polygonaceae Rheum officinale;Suitability:Pyridine,sodium bicarbonate;Store the product in sealed,cool and dry condition ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000015543

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific
Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.


DMSO by Affix Scientific
10 mM in DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO <1 mg/mL (<1 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Autophagy
Target Autophagy
Research Area Others

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Rhein - Not Found
Rhein - No Development Reported

Safety Data of Rhein

Hazard Symbols : Xi
Risk Statements : R36/37/38
Safety Statements : S26;S37/39
RTECS : CA9516000
WGKGermany : 2

Spectral Information


Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
ALB Technology Limited 20mg/USD70() China
AdooQ BioScience, LLC USA
Affix Scientific USA
Aladdin 20mg/RMB175() China
Alfa Chemistry USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
AvaChem Scientific LLC 20mg/USD59();100mg/USD85();1g/USD279();5g/USD790() USA
BLD Pharmatech
BOC Sciences 20g/USD190(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();200mg/USD96() USA
Cayman Chemical Company 100mg/USD49();250mg/USD116();500mg/USD221();1g/USD392() USA
Chengdu Forest Science and Technology Development Co., Ltd. China
Dibo Chemicals 1g/RMB166();5g/RMB455() China
Fluorochem United Kingdom
Hebei KaisTech Fine Chem Co., Ltd. China
Henan Newland Pharmaceutical Co., Ltd. China
MAYA-R 20mg/RMB210();1g/RMB800();5g/RMB1800() China
MedChemexpress Co., Ltd. 100mg/USD60();200mg/USD96() USA
MedKoo Biosciences, Inc. USA
Phytomarker Ltd. China
Santa Cruz Biotechnology, Inc. 100mg/USD252();500mg/USD420() USA
Selleck Chemicals LLC 100mg/USD70(In stock);200mg/USD120(In stock) USA
Shaanxi Green Bio-Engineering Co., Ltd. China
Shaanxi Sciphar Biotechnology Co., Ltd. China
Shangh Hai Haoran Biological Technology Co.,LTD 100mg/RMB1428();500mg/RMB5712();1g/RMB10608() China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();200mg/USD96() China
Sigma-Aldrich, Inc. 10mg/USD141();50mg/USD534() USA
Taizhou Highsun Pharmaceutical Co., Ltd. China
Target Molecule Corp. 5mg/USD20();25mg/USD60();100mg/USD128();200mg/USD228() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 200mg/RMB518();1g/RMB1860() China
Tokyo Chemical Industry Co., Ltd. 200mg/USD146();1g/USD492() Japan
Unoscientific Co., Ltd. China
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD70() China

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DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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