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27200-12-0 (Dihydromyricetin)

1

Identification

Dihydromyricetin Dihydromyricetin
Name Dihydromyricetin
Formula C15H12O8
MW 320.25
CAS No. 27200-12-0
EINECS
Smiles O=C1[[email protected]](O)[[email protected]@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
Synonyms Ampelopsin (flavanol); Ampeloptin; Dihydromyricetin; (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
InChI InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
2

Introduction

Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling.

Background Information

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. ......by BOC Sciences
Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). ......by MedChemexpress Co., Ltd.
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. ......by Selleck Chemicals LLC
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000015536

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO: ≥5 mg/mL (warmed) by CHEMSCENE, LLC
DMSO: ≥5 mg/mL (warmed) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 64 mg/mL (199.84 mM); Ethanol64 mg/mL (199.84 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways PI3K/Akt/mTOR Autophagy
Target mTOR Autophagy
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dihydromyricetin - Not Found
Dihydromyricetin - No Development Reported
7

Safety Data of Dihydromyricetin

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD78() USA
Changsha Staherb Natural Ingredients Co., Ltd. China
Chaozhou Zerun Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD78() USA
Microherb Inc. China
Ningbo Dekang Biochem Co., Ltd. China
Selleck Chemicals LLC 5mg/USD170(In stock);10mM/1mLIn DMSO/USD220(In stock);10mg/USD320(In stock);50mg/USD970(In stock);200mg/USD2470(In stock) USA
Shanghai Forever Biotech Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD78() China
Target Molecule Corp. 5mg/USD24();10mg/USD43();20mg/USD67();100mg/USD177();250mg/USD329() USA
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Related Products

Other Forms of 27200-12-0

Name CAS No Formula MW

Recommended Compounds in mTOR Autophagy

Name CAS No Formula MW
SAR245409 934493-76-2 C13H14N6O 270.29
AP20187 195514-80-8 C82H107N5O20 1482.75
Nandrolone 434-22-0 C18H26O2 274.4
LY 303511 154447-38-8 C19H18N2O2 306.36
XL388 1251156-08-7 C23H22FN3O4S 455.5
Salidroside 10338-51-9 C14H20O7 300.3
nandrolone decanoate 360-70-3 C28H44O3 428.65
mTOR-IN-1 1207358-59-5 C25H30N8O2 474.56
ETP-46464 1345675-02-6 C30H22N4O2 470.52
AP1903 195514-63-7 C78H98N4O20 1411.63
QL-IX-55 1223002-54-7 C24H14F4N4O 450.39
WAY-600 1062159-35-6 C28H30N8O 494.59
WYE-687 1062161-90-3 C28H32N8O3 528.61
GDC-0349 1207360-89-1 C24H32N6O3 452.55
AZD2014 1009298-59-2 C25H30N6O3 462.54
PF-04691502 1013101-36-4 C22H27N5O4 425.48
BEZ235 (Tosylate) 1028385-32-1 C37H31N5O4S 641.74
GNE-477 1032754-81-6 C21H28N8O3S2 504.63
GNE-493 1033735-94-2 C17H20N6O2S 372.44
PI-103 (Hydrochloride) 371935-79-4 C19H17ClN4O3 384.82

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Dihydromyricetin

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