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59277-89-3 (Acyclovir)

1

Identification

Acyclovir Acyclovir
Name Acyclovir
Formula C8H11N5O3
MW 225.2
CAS No. 59277-89-3
EINECS 261-685-1
Smiles O=C1NC(N)=NC2=C1N=CN2COCCO
Synonyms Aciclovir;Acycloguanosine; 2-amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one
InChI InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
2

Introduction

Acyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug.

Background Information

Aciclovir is an antiviral agent primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of varicella zoster (chickenpox) and herpes zoster (shingles). It was seen as the start of a new era in antiviral therapy, as it is extremely selective and low in cytotoxicity. ......by AdooQ BioScience, LLC
Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication. ......by BioVision, Inc.,
Acyclovir, a GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes. Acyclovir is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. ......by MedKoo Biosciences, Inc.
An antiviral agent that competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes; primarily used for the treatment of HSV infections.HSV InfectionApproved ......by ProbeChem
Aciclovir is a synthetic nucleoside analogue active against herpesviruses. ......by Selleck Chemicals LLC
Acyclovir is a synthetic nucleoside analogue active against herpesviruses. It is a guanosine analogue antiviral drug. Aciclovir differs from previous nucleoside analogues in that it contains only a partial nucleoside structure: the sugar ring is replaced by an open-chain structure. ......by Target Molecule Corp.
Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy). ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000015361

Storage condition

Solubility

DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 45 mg/mL (199.82 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Anti-infection
Target HSV
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Acyclovir - No Development Reported
Acyclovir - Launched
7

Safety Data of Acyclovir

Hazard Symbols : Xi,Xn
Risk Statements : 36/37/38-40-20/21/22
Safety Statements : 22-24/25-36-26-23
RTECS : UP0791400
WGKGermany : 2
8

Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Abcam 100mg/USD109() USA
AdooQ BioScience, LLC USA
Aladdin 1g/RMB199();5g/RMB399();25g/RMB999() China
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Astatech, Inc. USA
BLD Pharmatech
BioVision, Inc., 250mg/USD265() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD60();100mg/USD96() USA
Cayman Chemical Company 25mg/USD35() USA
Changzhou Kony Pharma Co., Ltd. China
Daqing New Century Fine Chemicals Co., Ltd. China
Dofly Biochemicals Co., Ltd. China
EMD Millipore 25mg/USD81() USA
Freedom Chemical Supply USA
Jiangsu Shanda Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD96() USA
MedKoo Biosciences, Inc. USA
Ningbo J &amp; S International Trade Co., CHINA
ProbeChem
Pure Chemistry Scientific Inc. 100g/USD91(In stock) USA
Rensin Chemicals Limited China
Santa Cruz Biotechnology, Inc. 50mg/USD107() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD163(in 1mL DMSO) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD96() China
Sigma-Aldrich, Inc. 50mg/USD102() USA
Siwei Development Co., Ltd. China
Spectrum Chemical Mfg. Corp. 1g/USD45() USA
Target Molecule Corp. 2mg/USD20();10mg/USD62();50mg/USD218();200mg/USD365() USA
Tocris Bioscience Inc. 50mg/USD95() USA
Tokyo Chemical Industry Co., Ltd. 1g/USD36() Japan
VDM BIOCHEMICALS,Inc. 50mg/USD50() USA
Xiamen Amoipharm Chemicals Co., Ltd. China
Yung Zip Chemical Co., Ltd. Taiwan, China
Zhejiang Oma Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 59277-89-3

Name CAS No Formula MW
Acyclovir elaidate 151090-37-8 C26H43N5O4 489.65

Recommended Compounds in HSV

Name CAS No Formula MW
Idoxuridine 54-42-2 C9H11IN2O5 354.1
Vidarabine 5536-17-4 C10H13N5O4 267.24
1-Docosanol 661-19-8 C22H46O 326.6
Valacyclovir (hydrochloride) 124832-27-5 0.0
Famciclovir 104227-87-4 C14H19N5O4 321.33
Valacyclovir 124832-26-4 C13H20N6O4 324.34
Penciclovir 39809-25-1 C10H15N5O3 253.26
Ganciclovir 82410-32-0 C9H13N5O4 255.23
BAY 57-1293 348086-71-5 C18H18N4O3S2 402.49
Fiacitabine 69123-90-6 C9H11FIN3O4 371.1
Valacyclovir (hydrochloride) 124832-27-5 C13H21ClN6O4 360.7966
Tromantadine 53783-83-8 C16H28N2O2 280.40572

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Acyclovir

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