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528-43-8 (Magnolol)

1

Identification

Magnolol Magnolol
Name Magnolol
Formula C18H18O2
MW 266.33
CAS No. 528-43-8
EINECS
Smiles OC1=C(C=C(CC=C)C=C1)C2=CC(CC=C)=CC=C2O
Synonyms 5,5'-Diallyl-2,2'-biphenyldiol; 5,5'-diallyl-[1,1'-biphenyl]-2,2'-diol
InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
2

Introduction

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.

Background Information

Magnolol (2,2'-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis).
......by AdooQ BioScience, LLC
Magnolol is an anxiolytic, anti-thrombotic and antibacterial. Magnolol (2,2’-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia(Magnolia officinalis). ......by Affix Scientific
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. ......by BOC Sciences
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively. ......by MedChemexpress Co., Ltd.
Magnolol is known to act on the GABAA receptors in rat cells in vitro as well as having antifungal properties. Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity. It has anti-periodontal disease activity in a rat model. Magnolol is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) or in M. grandiflora. The compound exists at the level of a few percent in the bark of species of magnolia, the extracts of which have been used in traditional Chinese and Japanese medicine. In addition to magnolol, related lignans occur in the extracts including honokiol, which is an isomer of magnolol. ......by MedKoo Biosciences, Inc.
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation. ......by Selleck Chemicals LLC
Magnolol is isomeric to honokiol (sc-202653). Magnolol is an anxiolytic,anti-thrombotic and antibacterial. . Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase(iNOS; NOS ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000015316

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific
4°C by MedChemexpress Co., Ltd.

Solubility

DMSO:37mg/mL by CHEMSCENE, LLC
DMSO:37mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 53 mg/mL (199.0 mM); Ethanol53 mg/mL (199.0 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy
Target RAR/RXR PPAR Autophagy
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Magnolol - Not Found
Magnolol - No Development Reported
7

Safety Data of Magnolol

Hazard Symbols : N
Risk Statements : R37/38;R41;R51/53
Safety Statements : S26;S39;S61
Transport Information : UN 3077
RTECS : DV5105500
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
ALB Technology Limited 20mg/USD70() China
AOBIOUS INC USA
Abcam 10mg/USD56();25mg/USD111();100mg/USD369() USA
Accela ChemBio Inc. 5g/USD60();25g/USD100();100g/USD295()
AdooQ BioScience, LLC 10mg/USD60();50mg/USD220();100mg/USD380() USA
Affix Scientific 1g/USD450(In stock);5g/USD650(In stock) USA
Aladdin 50mg/RMB156();250mg/RMB498() China
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD62();50mg/USD180() USA
Cayman Chemical Company 5mg/USD29();10mg/USD55();25mg/USD116() USA
Changsha Staherb Natural Ingredients Co., Ltd. China
Enzo Life Sciences International Inc. 5mg/USD56();25mg/USD253() USA
Guangxi Changzhou Natural Products Development Co., Ltd. China
Guangzhou Honsea Sunshine Bio Science & Technology Co., Ltd. China
Jiangxi Jishui Weiba Flavor Company CHINA
MAYA-R 1g/RMB500();5g/RMB1650() China
Matrix Scientific 1g/USD185();5g/USD500(inquire) USA
MedChemexpress Co., Ltd. 10mg/USD62();50mg/USD180() USA
MedKoo Biosciences, Inc. USA
Plantsman Ltd. China
Pure Chemistry Scientific Inc. 5g/USD85(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD56();25mg/USD246() USA
Selleck Chemicals LLC 10mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);25mg/USD120(In stock) USA
Shangh Hai Haoran Biological Technology Co.,LTD 5mg/RMB796() China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD62();50mg/USD180() China
Shanghai Orient Chemical Co., Ltd. China
Sigma-Aldrich, Inc. 10mg/USD115() USA
Target Molecule Corp. 10mg/USD20();25mg/USD40();50mg/USD75();250mg/USD198() USA
Tianjin Zhongxin Chem-tech Co., Ltd. China
Tokyo Chemical Industry Co., Ltd. 200mg/USD72();1g/USD241() Japan
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD70() China
10

Related Products

Other Forms of 528-43-8

Name CAS No Formula MW

Recommended Compounds in RAR/RXR PPAR Autophagy

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 196996 958295-17-5 C24H20BrNO5 482.32
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Acitretin 55079-83-9 C21H26O3 326.43
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Isotretinoin 4759-48-2 C20H28O2 300.44
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
(R)-Flurbiprofen 51543-40-9 C15H13FO2 244.2609
Tamibarotene 94497-51-5 C22H25NO3 351.44
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Magnolol

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