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331-39-5 (Caffeic acid)



Caffeic acid Caffeic acid
Name Caffeic acid
Formula C9H8O4
MW 180.16
CAS No. 331-39-5
EINECS 206-361-2
Smiles OC1=C(O)C=CC(/C=C/C(O)=O)=C1
Synonyms 3,4-Dihydroxycinnamic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
InChI InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+


Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.

Background Information

Caffeic acid inhibited 5-lipoxygenase in a non-competitive manner. Caffeic acid and its methyl ester did not inhibit prostaglandin synthase activity at all, at least up to 5 X 10(-4) M, but rather stimulate at higher doses.Caffeic acid has been shown to inhibit arachidonic acid metabolism in platelets at high doses.It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.Caffeic acid inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy.Caffeic acid inhibits Cu2+-induced LDL oxidation. ......by AbMole BioScience
Caffeic acid is an organic compound that is classified as hydroxycinnamic acid. ......by AdooQ BioScience, LLC
Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. ......by BOC Sciences
A histone-lysine demethylase (HKDM) inhibitor. Inhibits the HDM JMJD2C/KDM4 C and uTX/KDM6A in low µM range. ......by BioVision, Inc.,
Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO). ......by MedChemexpress Co., Ltd.
Extracted from Solidago decurrens,large-fruited Chinese hawthorn;Suitability:Hot water and cold ethanol;Store the product in sealed,cool and dry condition ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:yellow to tan EBNumber:EB000015309

Storage condition


(25°C) * In vitro DMSO 36 mg/mL (199.82 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways
Research Area

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Caffeic acid - No Development Reported

Safety Data of Caffeic acid

Hazard Symbols : Xn
Risk Statements : R36/37/38;R40
Safety Statements : S26;S36/37/39
HS Code : 29182990
RTECS : GD8950000
WGKGermany : 3

Spectral Information


Suppliers List


Related Products

Other Forms of 331-39-5

Name CAS No Formula MW
Caffeic acid amide 1202-41-1 C9H9NO3 179.1727

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis



Protocol Reference


More Information

Caffeic acid

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