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464-92-6 (Asiatic acid)

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Identification

Asiatic acid Asiatic acid
Name Asiatic acid
Formula C30H48O5
MW 488.7
CAS No. 464-92-6
EINECS 482-720-9
Smiles C[[email protected]@]12CC[[email protected]]([[email protected]@](CO)(C)[[email protected]]3O)([H])[[email protected]@](C[[email protected]]3O)(C)[[email protected]@]1([H])CC=C4[[email protected]@]2(C)CC[[email protected]](CC5)(C(O)=O)[[email protected]@]4([H])[[email protected]@H](C)[[email protected]@H]5C
Synonyms (1S,2R,4aS,6aR,6aS,6bR,8aR,9S,10S,11R,12aS,14bR)-10,11-Dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid; (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
InChI InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
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Introduction

Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.

Background Information

Apoptosis inducer [1, 3]. Cell cycle arrest inducer [1]. Anticancer compound [1, 5] Antioxidant. Hepatoprotective [2]. Inhibits TGF-β/Smad-mediated fibrogenesis [12]. Stimulates wound healing [4]. Anti-diabetic. Glycogen phosphorylase inhibitor [6]. Neuroprotective [13]. Modulates multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance. Down regulates BACE1 and increases ADAM10 maturation [7]. Anti-hyperglycemic compound [8, 14]. Anti-inflammatory and antinociceptive compound [9]. Antiangiogenic [10]. Acetylcholinesterase (AChE) inhibitor [11]. PPARγ inhibitor through a C/EBPβ-independent mechanisms [15]. Anti-osteoporotic. Inhibits adipogenic differentiation of bone marrow stromal cells (BMSC) [15]. ......by Adipogen Corporation

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

......by AdooQ BioScience, LLC
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. ......by BOC Sciences
Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, including C. asiatica, used in traditional medicines. In addition to anti-inflammatory actions, asiatic acid stimulates wound healing by increasing collagen production. It has been found to induce cell cycle arrest and apoptosis in breast cancer cells and block angiogenesis in cells and tumors from glioblastomas. It also reduces neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice while demonstrating protective effects against glutamate-induced apoptosis in isolated SH-SY5Y cells. ......by MedKoo Biosciences, Inc.
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. ......by Selleck Chemicals LLC
ActionsAsiatic acid is commonly used in wound healing. Asiatic acid has antioxidant,anti-inflammatory and neuroprotective properties.Packaging500 mg in glass bottleApplicationStarting material for asiatic acid derivative synthesis for use as: Anticance ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000015287

Storage condition

Solubility

(25°C) * In vitro DMSO 97 mg/mL (198.48 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Asiatic acid - No Development Reported
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Safety Data of Asiatic acid

Hazard Symbols : Xi
WGKGermany : 3
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 464-92-6

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

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More Information

Asiatic acid

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