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872728-81-9 (Dabigatran etexilate (mesylate))

1

Identification

Dabigatran etexilate (mesylate) Dabigatran etexilate (mesylate)
Name Dabigatran etexilate (mesylate)
Formula C35H45N7O8S
MW 723.84
CAS No. 872728-81-9
EINECS
Smiles O=C(N(C1=NC=CC=C1)CCC(OCC)=O)C2=CC=C3C(N=C(N3C)CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4)=C2.CS(=O)(O)=O
Synonyms Pradaxa;BIBR 1048MS;Dabigatran etexilate methanesulfonate; ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate
InChI InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)
2

Introduction

Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran.

Background Information

Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. ......by AdooQ BioScience, LLC
Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. It is a reversible and selective, direct thrombin inhibitor (DTI). ......by BOC Sciences
Dabigatran etexilate, also known as BIBR 1048MS, is a direct thrombin inhibitor. Dabigatran is used to prevent strokes in those with atrial fibrillation not caused by heart valve issues, as well as deep vein thrombosis and pulmonary embolism in persons who have been treated for 5–10 days with parenteral anticoagulant (usually low molecular weight heparin), and to prevent deep vein thrombosis and pulmonary embolism in some circumstances. It appears to be as effective as warfarin in preventing nonhemorrhagic strokes and embolic events in those with atrial fibrillation not due to valve problems. ......by MedKoo Biosciences, Inc.
A prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM; 10-fold less potent for Trypsin and no activity against Factor Xa, Plasmin, tPA and activated protein C; exhibits strong and long-lasting anticoagulant effects ex vivo and strong oral activity in different animal species.ThrombosisApproved ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000015190

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dabigatran etexilate (mesylate) Vanderbilt University Stroke 2013/10/31 2016/10/31 Phase 4 Clinical
Dabigatran etexilate (mesylate) Boehringer Ingelheim Pharmaceuticals Inc Atrial fibrillation 2013/7/31 2014/1/31 Phase 4 Clinical
Dabigatran etexilate (mesylate) Boehringer Ingelheim Pharmaceuticals Inc Atrial fibrillation 2013/1/31 2017/2/28 Phase 4 Clinical
Dabigatran etexilate (mesylate) Northwestern University Blood clotting disorder 2012/10/31 2014/12/31 Phase 4 Clinical
Dabigatran etexilate (mesylate) University of Utah Fibrosis 2012/2/29 Phase 4 Clinical
Dabigatran etexilate (mesylate) - Launched
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Safety Data of Dabigatran etexilate (mesylate)

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 872728-81-9

Name CAS No Formula MW
Dabigatran etexilate 211915-06-9 C34H41N7O5 627.73

Recommended Compounds in Thrombin

Name CAS No Formula MW
Argatroban (monohydrate) 141396-28-3 C23H38N6O6S 526.6494
Argatroban 74863-84-6 C23H36N6O5S 508.63
Metolazone 17560-51-9 C16H16ClN3O3S 365.83
Napsagatran hydrate 159668-20-9 C26H36N6O7S 576.67
Napsagatran 154397-77-0 C26H34N6O6S 558.65
Bivalirudin (Trifluoroacetate) 128270-60-0 C98H138N24O33 2180.29
Dabigatran (ethyl ester hydrochloride) 211914-50-0 C27H30ClN7O3 536.0252
Dabigatran (ethyl ester) 429658-95-7 C27H29N7O3 499.56
Dabigatran 211914-51-1 C25H25N7O3 471.51
Vorapaxar sulfate 705260-08-8 C29H35FN2O8S 590.66
Dabigatran etexilate 211915-06-9 C34H41N7O5 627.73
Inogatran 155415-08-0 C21H38N6O4 438.56
RWJ-445167 226566-43-4 C18H24N6O5S 436.49
AEBSF 30827-99-7 C8H11ClFNO2S 239.69
Sfllrnpndkyepf 137339-65-2 C81H118N20O23 1739.92382
NQ301 130089-98-4 C18H12ClNO3 0.0
Desethyl KBT-3022 101001-72-3 C23H20N2O4S 420.4809
RWJ-671818 C18H23F2N7O3 423.42
Dabigatran (D4 hydrochloride) C25H22D4ClN7O3 511.9967
Bivalirudin (Trifluoroacetate) 128270-60-0 C100H138DF3N24O35 2295.314831378

Recommended Compounds in Same Indication

Name CAS No Formula MW
Vernakalant 794466-70-9 C20H31NO4 349.46
Colchicine 64-86-8 C22H25NO6 399.44
5-R-Rivaroxaban 865479-71-6 C19H18ClN3O5S 435.88
Vernakalant (Hydrochloride) 748810-28-8 C20H32ClNO4 385.93
Rivaroxaban 366789-02-8 C19H18ClN3O5S 435.88
Edoxaban 480449-70-5 C24H30ClN7O4S 548.06
Edoxaban (tosylate) 480449-71-6 C31H38ClN7O7S2 720.26
Apixaban 503612-47-3 C25H25N5O4 459.5
Amiodarone (hydrochloride) 19774-82-4 C25H30ClI2NO3 681.77
Betrixaban 330942-05-7 C23H22ClN5O3 451.91
Capadenoson 544417-40-5 C25H18ClN5O2S2 520.03
Atorvastatin (hemicalcium salt) 134523-03-8 C66H68CaF2N4O10 1155.34
Dronedarone (Hydrochloride) 141625-93-6 C31H45ClN2O5S 593.22
Dronedarone 141626-36-0 C31H44N2O5S 556.76
Dabigatran 211914-51-1 C25H25N7O3 471.51
Dabigatran etexilate 211915-06-9 C34H41N7O5 627.73
VITAMIN K1 12001-79-5 C31H46O2 450.7
Heparin 9005-49-6 C26H42N2O37S5 1134.93
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Route of Synthesis

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References

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More Information

Dabigatran etexilate (mesylate)

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