• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1366002-50-7 (Senexin A)

1

Identification

Senexin A Senexin A
Name Senexin A
Formula C17H14N4
MW 274.32
CAS No. 1366002-50-7
EINECS
Smiles N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1
Synonyms 4-(phenethylamino)quinazoline-6-carbonitrile
InChI InChI=1S/C17H14N4/c18-11-14-6-7-16-15(10-14)17(21-12-20-16)19-9-8-13-4-2-1-3-5-13/h1-7,10,12H,8-9H2,(H,19,20,21)
2

Introduction

Senexin A is a CDK8 inhibitor with an IC50 of 280 nM.

Background Information

Senexin A is a selective Cell division protein kinase 8 (CDK8) inhibitor with IC50 value of 280 nM. Senexin A can bind to cdk19 in an ATP-competitive manner and it can also inhibit p21-induced transcription. Senexin A may inhibit the activation of tumor-p ......by BOC Sciences
Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. ......by MedChemexpress Co., Ltd.
Senexin A is a potent and selective CDK8 inhibitor (IC50 = 280 nM). Senexin A binds to cdk19 in an ATP-competitive manner. Senexin A inhibits p21-induced transcription. Senexin A may exert the effects against the activation of tumor-promoting and pro-inflammatory secreted factors in the tumor microenvironment by preventing transcriptional activation of NFκB-induced genes. ......by MedKoo Biosciences, Inc.
A selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively; inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells; suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts and reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin. ......by ProbeChem
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. ......by Selleck Chemicals LLC
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000014749

Storage condition

Solubility

DMSO: ≥100 mg/mL by CHEMSCENE, LLC
DMSO: ≥100 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Senexin A - No Development Reported
7

Safety Data of Senexin A

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 2mg/USD100();5mg/USD150() USA
MedChemexpress Co., Ltd. 2mg/USD100();5mg/USD150() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 2mg/USD100();5mg/USD150() China
10

Related Products

Other Forms of 1366002-50-7

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Senexin A

Tags: buy 1366002-50-7 IC50 | 1366002-50-7 price | 1366002-50-7 cost | 1366002-50-7 solubility | 1366002-50-7 purchase | 1366002-50-7 manufacturer | 1366002-50-7 research buy | 1366002-50-7 order | 1366002-50-7 MSDS | 1366002-50-7 chemical structure | 1366002-50-7 Storage condition | 1366002-50-7 molecular weight | 1366002-50-7 mw | 1366002-50-7 datasheet | 1366002-50-7 supplier | 1366002-50-7 cell line | 1366002-50-7 NMR | 1366002-50-7 MS | 1366002-50-7 IR | 1366002-50-7 solubility | 1366002-50-7 Safe information | 1366002-50-7 Qc and Spectral Information | 1366002-50-7 Clinical Information | 1366002-50-7 Clinical Trial | 1366002-50-7 Route of Synthesis | 1366002-50-7 storage condition | 1366002-50-7 diseases and conditions | 1366002-50-7 flash point | 1366002-50-7 boiling point | 1366002-50-7 melting point | 1366002-50-7 storage condition | 1366002-50-7 brand