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1366002-50-7 (Senexin A)

1

Identification

Senexin A Senexin A
Name Senexin A
Formula C17H14N4
MW 274.32
CAS No. 1366002-50-7
EINECS
Smiles N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1
Synonyms 4-(phenethylamino)quinazoline-6-carbonitrile
InChI InChI=1S/C17H14N4/c18-11-14-6-7-16-15(10-14)17(21-12-20-16)19-9-8-13-4-2-1-3-5-13/h1-7,10,12H,8-9H2,(H,19,20,21)
2

Introduction

Senexin A is a CDK8 inhibitor with an IC50 of 280 nM.

Background Information

Senexin A is a selective Cell division protein kinase 8 (CDK8) inhibitor with IC50 value of 280 nM. Senexin A can bind to cdk19 in an ATP-competitive manner and it can also inhibit p21-induced transcription. Senexin A may inhibit the activation of tumor-p ......by BOC Sciences
Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000014749

Storage condition

Solubility

DMSO: ≥100 mg/mL by CHEMSCENE, LLC
DMSO: ≥100 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Senexin A - No Development Reported
7

Safety Data of Senexin A

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 2mg/USD100();5mg/USD150() USA
MedChemexpress Co., Ltd. 2mg/USD100();5mg/USD150() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 2mg/USD100();5mg/USD150() China
10

Related Products

Other Forms of 1366002-50-7

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Senexin A

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