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56-25-7 (Cantharidin)

1

Identification

Cantharidin Cantharidin
Name Cantharidin
Formula C10H12O4
MW 196.2
CAS No. 56-25-7
EINECS 200-263-3
Smiles C[[email protected]]1(C(O2)=O)[[email protected]](C2=O)(C)[[email protected]]3([H])CC[[email protected]@]1([H])O3
Synonyms Dimethyl-3,6-epoxyperhydrophthalic anhydride; (1R,2S,3R,6S)-1,2-Dimethyl-3,6-epoxycyclohexane-1,2-dicarboxylic anhydride; (3aR,4S,7R,7aS)-3a,7a-dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
InChI InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
2

Introduction

Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.

Background Information

Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC₅₀ = 1.7 μM) and PP2A (IC₅₀ = 0.2 μM) and only weakly inhibits the activity of PP2B (IC₅₀ = 1 mM). ......by BioVision, Inc.,
Cantharidine is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity of osteoclasts. This compound can produce severe skin inflammation, and is extremely toxic if ingested orally ......by MedKoo Biosciences, Inc.
Extracted from (Meloidae),Mylabris phalerata Pallas,Mylabris cichorii L.de; Suitability:Acetone,chloroform,ether and ethyl acetate;Store the product in sealed,cool and dry condition ......by Target Molecule Corp.
Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000014716

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Cantharidin - No Development Reported
Cantharidin - Phase 2
7

Safety Data of Cantharidin

Hazard Symbols : T+
Risk Statements : R28;R36/37/38
Safety Statements : S53;S45
Transport Information : UN 2811
RTECS : RN8575000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
ALB Technology Limited 20mg/USD70() China
Abcam 25mg/USD48();100mg/USD123() USA
Adipogen Corporation USA
Aktin Chemicals Inc China
Aladdin 25mg/RMB369();100mg/RMB1190();500mg/RMB4599() China
Alfa Chemistry USA
Apexbio Technology LLC USA
AvaChem Scientific LLC USA
Baoji Herbest Bio-Tech Co., Ltd. China
BioVision, Inc., 10mg/USD65();50mg/USD255() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 25mg/USD60();50mg/USD96() USA
Cayman Chemical Company 25mg/USD36();100mg/USD108() USA
Changsha Staherb Natural Ingredients Co., Ltd. China
Chengdu Biopurify Phytochemicals Ltd. China
Chengdu Herbpurify Co., Ltd. China
Enzo Life Sciences International Inc. 25mg/USD58();100mg/USD183() USA
MAYA-R 20mg/RMB210() China
MedChemexpress Co., Ltd. 25mg/USD60();50mg/USD96() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 25mg/USD57();100mg/USD178() USA
Shaanxi Green Bio-Engineering Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 25mg/USD60();50mg/USD96() China
Shanghai Tauto Biotech Co., Ltd. China
Sigma-Aldrich, Inc. 25mg/USD60();100mg/USD178();500mg/USD647() USA
Target Molecule Corp. 25mg/USD47();50mg/USD76();100mg/USD118();250mg/USD208();500mg/USD378() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 5mg/RMB272() China
Tocris Bioscience Inc. 50mg/USD125() USA
10

Related Products

Other Forms of 56-25-7

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Cantharidin

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