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1402601-82-4 (TUG-770)

1

Identification

TUG-770 TUG-770
Name TUG-770
Formula C19H14FNO2
MW 307.32
CAS No. 1402601-82-4
EINECS
Smiles FC1=C(CCC(O)=O)C=CC(C#CC2=C(CC#N)C=CC=C2)=C1
Synonyms TUG770;TUG 770; 3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid
InChI InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
2

Introduction

TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1. IC50 Value: 6 nM (hFFA1, EC50) [1] Target: GPR40 in vitro: TUG-770 (Compound 22) displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB).

Background Information

TUG-770 is a Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ......by AdooQ BioScience, LLC
TUG-770 displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liv ......by BOC Sciences
TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently maintains normal glucose level in diet induced obese mice with fully sustained effect after 29 days of chronic dosing. ......by BioVision, Inc.,
TUG-770 is a Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000014313

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TUG-770 - Discovery
TUG-770 - No Development Reported
7

Safety Data of TUG-770

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Aladdin 10mg/RMB5301() China
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Arking Pharma 1g/USD3000() Canada
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD278();10mg/USD426() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD278();10mg/USD426() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD278();10mg/USD426() China
10

Related Products

Other Forms of 1402601-82-4

Name CAS No Formula MW

Recommended Compounds in GPR40

Name CAS No Formula MW
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 455.45
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 460.42
GPR40 Activator 1 1309435-60-6 C31H31NO3S 497.65
AMG 837 865231-46-5 C26H21F3O3 438.44
GW9508 885101-89-3 C22H21NO3 347.41
TAK-875 1000413-72-8 C29H32O7S 524.63
GW-1100 306974-70-9 C27H25FN4O4S 520.58
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 539.66
DC260126 346692-04-4 C32H31N5O 501.62
M-I C19H22O5S 362.44
T-1676427 1000414-39-0 C29H32O8S 540.62
JTT-851 C23H28O3 352.47
Astellas C27H30N4O4 474.55
MK-2305 905723-46-8 C19H13ClF3NO4S 443.82
Mochida 1469495-84-8 C30H35NO6S 537.67
BMS-986118 1610562-74-7 C25H28ClF3N4O4 540.96
AM-6226 C32H36F2O4 522.62
GPR40 agonist 1 1312788-44-5 C24H20O3 356.41
GPR40 agonist 2 C25H22O3 370.44
GPR40 agonist 3 C23H18O3 342.39

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

TUG-770

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