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194423-15-9 (PD168393)

1

Identification

PD168393 PD168393
Name PD168393
Formula C17H13BrN4O
MW 369.2153
CAS No. 194423-15-9
EINECS
Smiles C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
Synonyms
InChI InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
2

Introduction

Background Information

PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). ......by BOC Sciences
PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Shelf life: >2 years if stored properly. Drug formulation: ......by MedKoo Biosciences, Inc.
PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC. ......by Selleck Chemicals LLC
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Athymic nude mice with A431 human epidermoid carcinoma
Dosage 58 mg/kg
Formulation 4% dimethylacetamide in aqueous 50 mM sodium lactate buffer (pH 4)
Administration i.p.
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:Light yellow to khaki Solid EBNumber:EB000014209

Storage condition

Solubility

DMSO: ≥ 30 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 30 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 74 mg/mL (200.42 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol10 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy
Target EGFR Autophagy
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PD168393 - No Development Reported
7

Safety Data of PD168393

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 5mg/USD65();25mg/USD255() USA
BOC Sciences
Biochempartner Co., Ltd 5mg/USD201();10mg/USD304() China
CHEMSCENE, LLC 2mg/USD60();5mg/USD84() USA
EMD Millipore 1mg/USD139() USA
Enzo Life Sciences International Inc. 1mg/USD228() USA
MedChemexpress Co., Ltd. 2mg/USD60();5mg/USD84() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 1mg/USD216() USA
Selleck Chemicals LLC 1mg/USD170(In stock);10mM/1mLIn DMSO/USD810(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 2mg/USD60();5mg/USD84() China
Sigma-Aldrich, Inc. 5mg/USD81();25mg/USD328() USA
Toronto Research Chemicals Inc. 1mg/USD150(2-3 weeks);10mg/USD1200() Canada
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Related Products

Other Forms of 194423-15-9

Name CAS No Formula MW

Recommended Compounds in EGFR Autophagy

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 520.03
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 491.34
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 636.46
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanol 481-74-3 C15H10O4 254.2375
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47
AST-1306 (TsOH) 1050500-29-2 C31H26ClFN4O5S 621.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

PD168393

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