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256925-03-8 (AL 082D06)

1

Identification

AL 082D06 AL 082D06
Name AL 082D06
Formula C23H24ClN3O2
MW 409.91
CAS No. 256925-03-8
EINECS
Smiles O=[N+](C1=CC=C(Cl)C(C(C2=CC=C(N(C)C)C=C2)C3=CC=C(N(C)C)C=C3)=C1)[O-]
Synonyms AL082D06;AL-082D06;D 06; 4,4'-((2-chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline)
InChI InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
2

Introduction

AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM.

Background Information

AL082D06 is a nonsteroidal glucocorticoid receptor antagonist. ......by AdooQ BioScience, LLC
AL 082D06, also called as D-06, is a selective nonsteroidal antagonist of glucocorticoid receptor (GR) (Ki= 210 nM) without significant activity on AR, PR, MR and ER(Ki > 10 uM). AL 082D06 binds competitively with steroids, likely occupying a similar site ......by BOC Sciences
AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM. ......by MedChemexpress Co., Ltd.
AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain. ......by MedKoo Biosciences, Inc.
AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000014200

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO:<10mg/mL by CHEMSCENE, LLC
DMSO:<10mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Endocrinology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AL 082D06 - No Development Reported
7

Safety Data of AL 082D06

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD420();10mg/USD600() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD600() USA
MedKoo Biosciences, Inc. USA
Shangh Hai Haoran Biological Technology Co.,LTD China
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD600() China
Target Molecule Corp. 2mg/USD234();5mg/USD343();10mg/USD493();25mg/USD825();100mg/USD1888() USA
10

Related Products

Other Forms of 256925-03-8

Name CAS No Formula MW

Recommended Compounds in Glucocorticoid Receptor

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Prednisolone (disodium phosphate) 125-02-0 C21H27Na2O8P 484.39
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Fluocinolone (Acetonide) 67-73-2 C24H30F2O6 452.49
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Dexamethasone (acetate) 1177-87-3 C24H31FO6 434.5
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
Cortisone 53-06-5 C21H28O5 360.44
Mometasone furoate 83919-23-7 C32H32Cl2O8 615.5
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

AL 082D06

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