• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

147127-20-6 (Tenofovir)

1

Identification

Tenofovir Tenofovir
Name Tenofovir
Formula C9H14N5O4P
MW 287.21
CAS No. 147127-20-6
EINECS
Smiles O=P(COC(C)CN1C=NC2=C1N=CN=C2N)(O)O
Synonyms 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid; (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
InChI InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)
2

Introduction

Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. IC50 Value:0.5-2.2 uM (HIV-1); 1.6-4.9 uM (HIV-2) [1] Target: NRTIs in vitro: Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells.

Background Information

Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. ......by AdooQ BioScience, LLC
Tenofovir is a selective antiretroviral agent which functions as a HIV reverse transcriptase inhibitor. Tenofovir functions by inhibiting the replication of this DNA. Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Tenofovir may reduce (not cure) the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood. ......by Affix Scientific
Tenofovir blocks reverse transcriptase and hepatitis B virus infections. ......by BOC Sciences
Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. ......by MedChemexpress Co., Ltd.
Tenofovir is an antiretroviral medication used to prevent and treat HIV/AIDS and to treat chronic hepatitis B.[1] The active substance is tenofovir, while tenofovir disoproxil is a prodrug that is used because of its better absorption in the gut. ......by MedKoo Biosciences, Inc.
Tenofovir blocks reverse transcriptase and hepatitis B virus infections. ......by Selleck Chemicals LLC
Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ......by Target Molecule Corp.
Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Macaques
Dosage 30 mg/kg
Formulation Saline
Administration Subcutaneously
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000014057

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

DMSO 4 mg/mL; Water 2 mg/mL; Ethanol <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 4 mg/mL warming (13.92 mM); Water2 mg/mL (6.96 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Anti-infection
Target Reverse Transcriptase HIV
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tenofovir - Launched
7

Safety Data of Tenofovir

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AdooQ BioScience, LLC USA
Affix Scientific 500mg/USD1395(In stock);1g/USD2150(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Astatech, Inc. USA
BLD Pharmatech
BOC Sciences
Baoji Aivchem Biotechnology Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD50();10mg/USD70() USA
Cayman Chemical Company 5mg/USD65() USA
Changzhou Huaren Chemical Co., Ltd. China
Daqing New Century Fine Chemicals Co., Ltd. China
Huangshi Fuertai Chemical Co., Ltd. China
Janlon Biopharma Co., Ltd. China
Jingmen Shuaibang Chemical Science and Technology Co., Ltd. China
Leping Safely Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 5mg/USD50();10mg/USD70() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 10mg/USD145() USA
Selleck Chemicals LLC 5mg/USD97(In stock);10mM/1mLIn DMSO/USD110(In stock);20mg/USD270(In stock);50mg/USD570(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD50();10mg/USD70() China
Suzhou Qilin Pharm-Chemicals Research Co., Ltd. China
Target Molecule Corp. 5mg/USD48();20mg/USD158();50mg/USD283();100mg/USD428() USA
Tocris Bioscience Inc. 10mg/USD149() USA
Wenzhou Zhongtai Chemical Co., Ltd. China
10

Related Products

Other Forms of 147127-20-6

Name CAS No Formula MW
Tenofovir (maleate) 1236287-04-9 C13H18N5O8P 403.28
Tenofovir (hydrate) 206184-49-8 C9H16N5O5P 305.23
Tenofovir (Disoproxil Fumarate) 202138-50-9 C23H34N5O14P 635.51

Recommended Compounds in Reverse Transcriptase HIV

Name CAS No Formula MW
Adefovir dipivoxil 142340-99-6 C20H32N5O8P 501.47
Lamivudine 134678-17-4 C8H11N3O3S 229.26
Didanosine 69655-05-6 C10H12N4O3 236.23
Abacavir (sulfate) 188062-50-2 C14H18N6O4S 366.4
Tenofovir (maleate) 1236287-04-9 C13H18N5O8P 403.28
Tenofovir (hydrate) 206184-49-8 C9H16N5O5P 305.23
Stavudine (sodium) 134624-73-0 C10H11N2NaO4 246.2
Stavudine 3056-17-5 C10H12N2O4 224.21
Delavirdine (mesylate) 147221-93-0 C23H32N6O6S2 552.67
Emtricitabine 143491-57-0 C8H10FN3O3S 247.25
Abacavir 136470-78-5 C14H18N6O 286.33
Tenofovir (Disoproxil Fumarate) 202138-50-9 C23H34N5O14P 635.51
Zalcitabine 7481-89-2 C9H13N3O3 211.22
GS-7340 379270-37-8 C21H29N6O5P 476.47
Lersivirine 473921-12-9 C17H18N4O2 310.35
Dapivirine 244767-67-7 C20H19N5 329.4
Efavirenz 154598-52-4 C14H9ClF3NO2 315.68
Delavirdine 136817-59-9 C22H28N6O3S 456.56
Nevirapine 129618-40-2 C15H14N4O 266.3
Rilpivirine 500287-72-9 C22H18N6 366.42

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Tenofovir

Tags: buy 147127-20-6 IC50 | 147127-20-6 price | 147127-20-6 cost | 147127-20-6 solubility | 147127-20-6 purchase | 147127-20-6 manufacturer | 147127-20-6 research buy | 147127-20-6 order | 147127-20-6 MSDS | 147127-20-6 chemical structure | 147127-20-6 Storage condition | 147127-20-6 molecular weight | 147127-20-6 mw | 147127-20-6 datasheet | 147127-20-6 supplier | 147127-20-6 cell line | 147127-20-6 NMR | 147127-20-6 MS | 147127-20-6 IR | 147127-20-6 solubility | 147127-20-6 Safe information | 147127-20-6 Qc and Spectral Information | 147127-20-6 Clinical Information | 147127-20-6 Clinical Trial | 147127-20-6 Route of Synthesis | 147127-20-6 storage condition | 147127-20-6 diseases and conditions | 147127-20-6 flash point | 147127-20-6 boiling point | 147127-20-6 melting point | 147127-20-6 storage condition | 147127-20-6 brand