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1446700-26-0 (CO-1686 (hydrobromide))

1

Identification

CO-1686 (hydrobromide) CO-1686 (hydrobromide)
Name CO-1686 (hydrobromide)
Formula C27H29BrF3N7O3
MW 636.46
CAS No. 1446700-26-0
EINECS
Smiles C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O.[H]Br
Synonyms AVL-301 hydrobromide;CNX-419 hydrobromide; N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide hydrobromide
InChI InChI=1S/C27H28F3N7O3.BrH/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38;/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35);1H
2

Introduction

CO-1686 hydrobromide is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

Background Information

CO-1686 hydrobromide is the hydrobromide salt form of CO-1686. CO-1686, also called as Rociletinib, is an oral tyrosine kinase inhibitor that irreversibly and selectively inhibits mutation of EGFR for treating Non-small cell lung cancer.Non-small cell lun ......by BOC Sciences
CO-1686 hydrobromide is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000014042

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

DMSO:59mg/mL by CHEMSCENE, LLC
DMSO:59mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications Non-small-cell lung cancer
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
CO-1686 (hydrobromide) Clovis Oncology Inc Non-small-cell lung cancer 2012/3/31 2015/9/30 Phase 2 Clinical
CO-1686 (hydrobromide) - No Development Reported
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Safety Data of CO-1686 (hydrobromide)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 10mg/USD150();50mg/USD400() USA
Aladdin 10mg/RMB1518();50mg/RMB4890() China
Apexbio Technology LLC 10mg/USD125();50mg/USD200();100mg/USD325() USA
BOC Sciences
BioVision, Inc., 5mg/USD145();25mg/USD575() USA
CHEMSCENE, LLC 5mg/USD60();10mg/USD96() USA
Cayman Chemical Company 1mg/USD55();5mg/USD165();10mg/USD275() USA
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD96() USA
MedKoo Biosciences, Inc. 10mg/USD120();50mg/USD250();100mg/USD350();200mg/USD450();500mg/USD550();1g/USD850();2g/USD1450();5g/USD2850();10g/USD3650() USA
Selleck Chemicals LLC 10mg/USD297();50mg/USD970() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD96() China
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Related Products

Other Forms of 1446700-26-0

Name CAS No Formula MW
CO-1686 1374640-70-6 C27H28F3N7O3 555.55

Recommended Compounds in EGFR

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 520.03
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 491.34
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
PD168393 194423-15-9 C17H13BrN4O 369.2153
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanol 481-74-3 C15H10O4 254.2375
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47
AST-1306 (TsOH) 1050500-29-2 C31H26ClFN4O5S 621.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Crizotinib 877399-52-5 C21H22Cl2FN5O 450.34
AT-101 90141-22-3 C30H30O8 518.55
Dovitinib 405169-16-6 C21H21FN6O 392.43
Retaspimycin 857402-23-4 C31H45N3O8 587.7
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 624.17
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 569.44
Anamorelin (hydrochloride) 861998-00-7 C31H43ClN6O3 583.16
LY2603618 911222-45-2 C18H22BrN5O3 436.3
AT13387 912999-49-6 C24H31N3O3 409.52
Carboplatin 41575-94-4 C6H12N2O4Pt 371.25
Vandetanib (hydrochloride) 524722-52-9 C22H25BrClFN4O2 511.81
Dinaciclib 779353-01-4 C21H28N6O2 396.49
XL-647 781613-23-8 C24H25Cl2FN4O2 491.39
YM-155 781661-94-7 C20H19BrN4O3 443.29
Crenolanib 670220-88-9 C26H29N5O2 443.54
Ezatiostat 168682-53-9 C27H35N3O6S 529.65
Roscovitine 186692-46-6 C19H26N6O 354.45
Vandetanib (trifluoroacetate) 338992-53-3 C24H25BrF4N4O4 589.38
Anamorelin (Fumarate) 339539-92-3 C35H46N6O7 662.78
Vinorelbine 71486-22-1 C45H54N4O8 778.93
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Route of Synthesis

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References

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More Information

CO-1686 (hydrobromide)

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