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1092364-38-9 (Poziotinib)

1

Identification

Poziotinib Poziotinib
Name Poziotinib
Formula C23H21Cl2FN4O3
MW 491.34
CAS No. 1092364-38-9
EINECS
Smiles C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
Synonyms UNII-OEI6OOU6IK; 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one
InChI InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
2

Introduction

Background Information

Poziotinib, also known as HM781-36B and NOV120101, is an?orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), incl ......by BOC Sciences
Poziotinib(NOV120101; HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000014041

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Poziotinib National OncoVenture Increased Drug Resistance 2012/10/22 Phase 2 Clinical
Poziotinib Hanmi Pharmaceutical Company Limited HER-2 Positive Advanced Gastric Cancer 2012/12/3 Phase 2 Clinical
Poziotinib - Phase 2
7

Safety Data of Poziotinib

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Active Biochem 5mg/USD120(In stock);10mg/USD200(In stock);25mg/USD320(In stock);50mg/USD620(In stock);100mg/USD950(In stock) USA
AdooQ BioScience, LLC 5mg/USD72() USA
BOC Sciences
BioVision, Inc., 10mg/USD125() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD96();10mg/USD132() USA
DC Chemicals 100mg/USD450(In stock) China
MedChemexpress Co., Ltd. 5mg/USD96();10mg/USD132() USA
MedKoo Biosciences, Inc. 5mg/USD90() USA
Selleck Chemicals LLC 5mg/USD147(In stock);25mg/USD477(In stock);100mg/USD997(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD96();10mg/USD132() China
Target Molecule Corp. 2mg/USD74();5mg/USD106();10mg/USD171();25mg/USD318();50mg/USD528() USA
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Related Products

Other Forms of 1092364-38-9

Name CAS No Formula MW

Recommended Compounds in EGFR

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 520.03
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 636.46
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
PD168393 194423-15-9 C17H13BrN4O 369.2153
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanol 481-74-3 C15H10O4 254.2375
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47
AST-1306 (TsOH) 1050500-29-2 C31H26ClFN4O5S 621.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Poziotinib

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