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1968-05-4 (3,3'-Diindolylmethane)

1

Identification

3,3'-Diindolylmethane 3,3'-Diindolylmethane
Name 3,3'-Diindolylmethane
Formula C17H14N2
MW 246.31
CAS No. 1968-05-4
EINECS
Smiles C1(C=CC=C2)=C2NC=C1CC3=CNC4=C3C=CC=C4
Synonyms di(1H-indol-3-yl)methane
InChI InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
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Introduction

DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed cancer preventive agent. IC50 Value: 65 uM (SKOV-3 cell, 72h) [1] Target: Apoptosis inducer in vitro: DIM caused rapid activation of ataxia-telangiectasia mutated (ATM), a nuclear kinase that regulates responses to DNA damage (DDR) and oxidative stress.

Background Information

3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. ......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
3,3’-Diindolylmethane is a derivative of a phytochemical natural compound found in Brassicaceae(Indole-3-carbinol).It is works as an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines.It also inhibits phosphorylation of EGFR ......by BOC Sciences
Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells. Recently, it has been shown that DIM induces apoptosis in ovarian cancer cells by inhibiting JAK2/STAT3. ......by BioVision, Inc.,
3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist. ......by MedChemexpress Co., Ltd.
DIM is an inducer of CYP3A4 and MDR1 gene expression by activating human PXR. ......by MedKoo Biosciences, Inc.
3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. ......by Selleck Chemicals LLC
DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed cancer preventive agent. ......by Target Molecule Corp.
Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013903

Storage condition

Store at +4°C by Tocris Bioscience Inc.

Solubility

25°C: DMSO by MedChemexpress Co., Ltd.
Soluble to 100 mM in DMSO and to 50 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Others
Target Androgen Receptor
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
3,3'-Diindolylmethane - Not Found
3,3'-Diindolylmethane - No Development Reported
3,3'-Diindolylmethane - Phase 4
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Safety Data of 3,3'-Diindolylmethane

Hazard Symbols : Xi
Risk Statements : 36/37/38
Safety Statements : 22-24/25-26
RTECS : NM0332000
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();200mg/USD72() USA
Cayman Chemical Company USA
Hangzhou Bm Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();200mg/USD72() USA
MedKoo Biosciences, Inc. USA
N&R Industries, Inc. China
Ningbo Sialon Chem Co., Ltd. China
Pure Chemistry Scientific Inc. 5g/USD29(In stock) USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();200mg/USD72() China
Target Molecule Corp. 10mg/USD20();25mg/USD40();50mg/USD78();250mg/USD198() USA
Tocris Bioscience Inc. USA
VMB Chem Bio Sys Pvt Ltd. India
Xishi Chemical (Shanghai) Co., Ltd. China
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Related Products

Other Forms of 1968-05-4

Name CAS No Formula MW

Recommended Compounds in Androgen Receptor

Name CAS No Formula MW
Lupeol 545-47-1 C30H50O 426.72
Oxandrolone 53-39-4 C19H30O3 306.44
Testosterone (undecanoate) 5949-44-0 C30H48O3 456.7003
Spironolactone 52-01-7 C24H32O4S 416.57
LGD-4033 1165910-22-4 C14H12F6N2O 338.25
Adrenosterone 382-45-6 C19H24O3 300.39
Triptophenolide 74285-86-2 C20H24O3 312.4
Epiandrosterone 481-29-8 C19H30O2 290.44
Boldenone Undecylenate 13103-34-9 C30H44O3 452.67
Testosterone 58-22-0 C19H28O2 288.42
Cyproterone (acetate) 427-51-0 0.0
GLPG0492 1215085-92-9 C19H14F3N3O3 389.328
N-desmethyl Enzalutamide 1242137-16-1 C20H14F4N4O2S 450.41
AZD3514 1240299-33-5 C25H32F3N7O2 519.56
ARN-509 956104-40-8 C21H15F4N5O2S 477.43
DHEA 53-43-0 C19H28O2 288.42
RAD140 1182367-47-0 C20H16ClN5O2 393.83
Cortexolone 17 alpha-propionate 19608-29-8 C24H34O5 402.5238
BMS-564929 627530-84-1 C14H12ClN3O3 305.72
MK-0773 606101-58-0 C27H34FN5O2 479.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

3,3'-Diindolylmethane

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