• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

221244-14-0 (1-NM-PP1)

1

Identification

1-NM-PP1 1-NM-PP1
Name 1-NM-PP1
Formula C20H21N5
MW 331.41
CAS No. 221244-14-0
EINECS
Smiles CC(N1N=C(CC2=CC=CC3=C2C=CC=C3)C4=C(N)N=CN=C41)(C)C
Synonyms PP1 Analog II;1-NM-PP 1; 1-(tert-butyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
2

Introduction

1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G). IC50 Value: 4.2 nM (v-Src-as1 I338G) [1] Target: Src Family Kinase PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.

Background Information

1-NM-PP1 inhibits Cdk7 recovered from the mutant, but not the wild-type cells with an IC50 of ~50 nM with either substrate. ......by MedChemexpress Co., Ltd.
1NM-PP1 is a potent Mutant Kinases Inhibitor. (12/25/2013) Shelf life: >2 years if stored properly Drug formulation: This drug may be formulated in DMSO ......by MedKoo Biosciences, Inc.
1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013842

Storage condition

Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
1-NM-PP1 - Not Found
1-NM-PP1 - No Development Reported
7

Safety Data of 1-NM-PP1

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 5mg/USD64() USA
Apexbio Technology LLC 5mg/USD90(In Stock) USA
Axon Medchem BV 5mg/USD114(In Stock) Netherlands
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD114();10mg/USD180() USA
Cayman Chemical Company 1mg/USD86() USA
Chendu Sinostandards Bio-Tech Co., Ltd 5mg/RMB3510() China
Clearsynth Labs Limited 25mg/USD5500() India
EMD Millipore 1mg/USD104() USA
MedChemexpress Co., Ltd. 5mg/USD114();10mg/USD180() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 1mg/USD94() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD114();10mg/USD180() China
Target Molecule Corp. 2mg/USD71();5mg/USD125();10mg/USD212();50mg/USD569() USA
10

Related Products

Other Forms of 221244-14-0

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

1-NM-PP1

Tags: buy 221244-14-0 IC50 | 221244-14-0 price | 221244-14-0 cost | 221244-14-0 solubility | 221244-14-0 purchase | 221244-14-0 manufacturer | 221244-14-0 research buy | 221244-14-0 order | 221244-14-0 MSDS | 221244-14-0 chemical structure | 221244-14-0 Storage condition | 221244-14-0 molecular weight | 221244-14-0 mw | 221244-14-0 datasheet | 221244-14-0 supplier | 221244-14-0 cell line | 221244-14-0 NMR | 221244-14-0 MS | 221244-14-0 IR | 221244-14-0 solubility | 221244-14-0 Safe information | 221244-14-0 Qc and Spectral Information | 221244-14-0 Clinical Information | 221244-14-0 Clinical Trial | 221244-14-0 Route of Synthesis | 221244-14-0 storage condition | 221244-14-0 diseases and conditions | 221244-14-0 flash point | 221244-14-0 boiling point | 221244-14-0 melting point | 221244-14-0 storage condition | 221244-14-0 brand