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4474-91-3 (Angiotensin II human)

1

Identification

Angiotensin II human Angiotensin II human
Name Angiotensin II human
Formula C50H71N13O12
MW 0.0
CAS No. 4474-91-3
EINECS
Smiles [H]N[[email protected]@H](CC(O)=O)C(=O)N[[email protected]@H](CCCNC(N)=N)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC1=CC=C(O)C=C1)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](CC1=CNC=N1)C(=O)N1CCC[[email protected]]1C(=O)N[[email protected]@H](CC1=CC=CC=C1)C(O)=O
Synonyms Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
InChI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
2

Introduction

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. IC50 value: Target: Angiotensin receptor In nature, angiotensin II (Ang II) is formed by the action of angiotensin converting enzyme (ACE), which cleaves the C-terminal -His-Leu from the decapeptide, angiotensin I.

Background Information

Angiotensin II (Ang II) is an octapeptide hormone that plays a central role in cardiovascular homeostasis. ......by AdooQ BioScience, LLC
Angiotensin II is an endogenous potent vasoconstrictor peptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE) by binding to both the AT1 and the AT2 receptors. ......by BOC Sciences
Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. ......by MedChemexpress Co., Ltd.
Angiotensin II is an endogenous potent vasoconstrictor peptide. The amino acid sequence of angiotensin II is Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | His-Leu. Angiotensin II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates an IP3-dependent mechanism leading to a rise in intracellular calcium levels and ultimately causing contraction). In addition, angiotensin II acts at the Na/H exchanger in the proximal tubules of the kidney to stimulate Na reabsorption and H excretion which is coupled to bicarbonate reabsorption. This ultimately results in an increase in blood volume, pressure, and pH. Angiotensin II is degraded to angiotensin III by angiotensinases located in red blood cells and the vascular beds of most tissues. It has a half-life in circulation of around 30 seconds, whereas, in tissue, it may be as long as 15–30 minutes. ......by MedKoo Biosciences, Inc.
Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013810

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Angiotensin Receptor
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Angiotensin II human - No Development Reported
7

Safety Data of Angiotensin II human

WGKGermany : 3
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Accurate Chemical And Scientific Corporation USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Aroz Technologies, LLC USA
BIOTREND Chemikalien GmbH GERMANY
BOC Sciences
CHEMSCENE, LLC 10mg/USD75();50mg/USD300() USA
Cayman Chemical Company 1mg/USD19() USA
EMD Millipore 1mg/USD39() USA
Matrix Scientific 250mg/USD742() USA
MedChemexpress Co., Ltd. 10mg/USD75();50mg/USD300() USA
MedKoo Biosciences, Inc. USA
Peptides International, Inc. USA
Santa Cruz Biotechnology, Inc. 1mg/USD24() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD75();50mg/USD300() China
Sigma-Aldrich, Inc. 1mg/USD25() USA
Tocris Bioscience Inc. 5mg/USD109() USA
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Related Products

Other Forms of 4474-91-3

Name CAS No Formula MW

Recommended Compounds in Angiotensin Receptor

Name CAS No Formula MW
Eprosartan (mesylate) 144143-96-4 C24H28N2O7S2 520.62
Losartan (potassium) 124750-99-8 C22H22ClKN6O 461.0
Losartan 114798-26-4 C22H23ClN6O 422.91
Candesartan (Cilexetil) 145040-37-5 C33H34N6O6 610.66
Candesartan 139481-59-7 C24H20N6O3 440.45
Irbesartan 138402-11-6 C25H28N6O 428.53
Tranilast (Sodium) 104931-56-8 C18H16NNaO5 349.31
Tranilast 53902-12-8 C18H17NO5 327.33
AVE 0991 (sodium salt) 306288-04-0 C29H31N4NaO5S2 602.7
AVE 0991 304462-19-9 C29H32N4O5S2 580.72
Telmisartan 144701-48-4 C33H30N4O2 514.62
Azilsartan (medoxomil monopotassium) 863031-24-7 C30H24KN4O8+ 607.63
PD 123319 (ditrifluoroacetate) 136676-91-0 C35H34F6N4O7 736.66
Valsartan 137862-53-4 C24H29N5O3 435.52
Azilsartan 147403-03-0 C25H20N4O5 456.45
Azilsartan (medoxomil) 863031-21-4 C30H24N4O8 568.53
PD 123319 130663-39-7 C31H32N4O3 508.61
Olmesartan (medoxomil) 144689-63-4 C29H30N6O6 558.59
Olmesartan 144689-24-7 C24H26N6O3 446.5
Angiotensin acetate 58-49-1 C51H73N13O14 1092.2

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Angiotensin II human

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