• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

6147-11-1 (alpha-Mangostin)

1

Identification

alpha-Mangostin alpha-Mangostin
Name alpha-Mangostin
Formula C24H26O6
MW 410.4596
CAS No. 6147-11-1
EINECS 448-420-7
Smiles O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
Synonyms α-Mangostin
InChI InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
2

Introduction

Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.

Background Information

It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent. ......by BOC Sciences
α-Mangostin, a naturally occurring xanthone, displays both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with an IC50 value of 5.54 μM noncompetitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. Its inhibitory activity is higher than classical FAS inhibitors such as C75, EGCG and curcumin. It induces apoptosis in breast cancer cells by inhibition of FAS. ......by BioVision, Inc.,
Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. ......by MedChemexpress Co., Ltd.
Alpha-Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. ......by MedKoo Biosciences, Inc.
Alpha-Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. ......by MedKoo Biosciences, Inc.
Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. ......by Selleck Chemicals LLC
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000013570

Storage condition

Solubility

DMSO: ≥ 37 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 37 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
alpha-Mangostin - No Development Reported
7

Safety Data of alpha-Mangostin

Hazard Symbols : T
Risk Statements : 25
Safety Statements : 45
8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 6147-11-1

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

alpha-Mangostin

Tags: buy 6147-11-1 IC50 | 6147-11-1 price | 6147-11-1 cost | 6147-11-1 solubility | 6147-11-1 purchase | 6147-11-1 manufacturer | 6147-11-1 research buy | 6147-11-1 order | 6147-11-1 MSDS | 6147-11-1 chemical structure | 6147-11-1 Storage condition | 6147-11-1 molecular weight | 6147-11-1 mw | 6147-11-1 datasheet | 6147-11-1 supplier | 6147-11-1 cell line | 6147-11-1 NMR | 6147-11-1 MS | 6147-11-1 IR | 6147-11-1 solubility | 6147-11-1 Safe information | 6147-11-1 Qc and Spectral Information | 6147-11-1 Clinical Information | 6147-11-1 Clinical Trial | 6147-11-1 Route of Synthesis | 6147-11-1 storage condition | 6147-11-1 diseases and conditions | 6147-11-1 flash point | 6147-11-1 boiling point | 6147-11-1 melting point | 6147-11-1 storage condition | 6147-11-1 brand