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92-61-5 (Scopoletin)

1

Identification

Scopoletin Scopoletin
Name Scopoletin
Formula C10H8O4
MW 192.17
CAS No. 92-61-5
EINECS 202-171-9
Smiles OC1=CC(O2)=C(C=CC2=O)C=C1OC
Synonyms 6-Methoxyumbelliferone; 7-Hydroxy-6-methoxycoumarin; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 7-hydroxy-6-methoxy-2H-chromen-2-one
InChI InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3
2

Introduction

Scopoletin is an inhibitor of acetylcholinesterase (AChE).

Background Information

Scopoletin, that comes from the herbs of Atropa belladonna L, can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet. Scopoletin exerts anti-RA action probably through su ......by BOC Sciences
Scopoletin is an inhibitor of acetylcholinesterase (AChE). ......by MedChemexpress Co., Ltd.
Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities. ......by Selleck Chemicals LLC
Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000013552

Storage condition

Solubility

DMSO: ≥ 32 mg/mL by CHEMSCENE, LLC
DMSO ≥ 32 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways NF-κB MAPK/ERK Pathway
Target p38 MAPK NF-κB
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Scopoletin - No Development Reported
7

Safety Data of Scopoletin

Hazard Symbols : Xi
Risk Statements : R36/37/38
Safety Statements : S26;S37/39
RTECS : GN6930000
WGKGermany : 2
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
Aktin Chemicals Inc China
Aladdin 50mg/RMB529();250mg/RMB1799();1g/RMB5499() China
Alfa Chemistry USA
Ark Pharm, Inc. USA
Astatech, Inc. USA
BOC Sciences
BioBioPha Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD84();100mg/USD108() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 50mg/USD84();100mg/USD108() USA
Phytomarker Ltd. China
Santa Cruz Biotechnology, Inc. 50mg/USD73();100mg/USD134() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD84();100mg/USD108() China
Shanghai Tauto Biotech Co., Ltd. China
Sigma-Aldrich, Inc. 50mg/USD82();100mg/USD152();500mg/USD563();1g/USD874() USA
Target Molecule Corp. 5mg/USD71();20mg/USD125();100mg/USD354() USA
Tokyo Chemical Industry Co., Ltd. 100mg/USD97();1g/USD564() Japan
Toronto Research Chemicals Inc. 25mg/USD50();50mg/USD65();100mg/USD95();250mg/USD180();500mg/USD300();1g/USD520() Canada
Xian Weijia Technology Co., Ltd. China
10

Related Products

Other Forms of 92-61-5

Name CAS No Formula MW
Scopoletin (acetate) 56795-51-8 C12H10O5 234.2

Recommended Compounds in p38 MAPK NF-κB

Name CAS No Formula MW
SB 203580 (hydrochloride) 869185-85-3 C21H17ClFN3OS 413.9
Bakuchiol 10309-37-2 C18H24O 256.38
SB 242235 193746-75-7 C19H20FN5O 353.39
Semapimod (tetrahydrochloride) 164301-51-3 C34H56Cl4N18O2 890.74
Semapimod 352513-83-8 C34H52N18O2 744.9
Skepinone-L 1221485-83-1 C24H21F2NO4 425.42
5-Aminosalicylic acid 89-57-6 C7H7NO3 153.14
R1487 (Hydrochloride) 449808-64-4 C19H19ClF2N4O3 424.829
BMS-582949 623152-17-0 C22H26N6O2 406.48
PD 169316 152121-53-4 C20H13FN4O2 360.34
SCIO-469 309913-83-5 C27H30ClFN4O3 513.0
Pamapimod 449811-01-2 C19H20F2N4O4 406.3833
SB-681323 444606-18-2 C23H19F3N4O3 456.42
Losmapimod 585543-15-3 C22H26FN3O2 383.46
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
SD-06 271576-80-8 C20H20ClN5O2 397.86
Doramapimod 285983-48-4 C31H37N5O3 527.66
LY2228820 862507-23-1 C26H37FN6O6S2 612.74
VX-745 209410-46-8 C19H9Cl2F2N3OS 436.26
SB 202190 152121-30-7 C20H14FN3O 331.34

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Scopoletin

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