• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1395084-25-9 (MS436)

1

Identification

MS436 MS436
Name MS436
Formula C18H17N5O3S
MW 383.42
CAS No. 1395084-25-9
EINECS
Smiles O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3=NC=CC=C3)=O
Synonyms MS-436;MS 436; (E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide
InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+
2

Introduction

MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. IC50 Value: 30-50 nM (Ki) [1] Target: BRD4 bromodomain MS436 exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference for the first bromodomain over the second.

Background Information

MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. ......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. ......by BOC Sciences
MS436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM for BrD1). It displays 10-fold selectivity for BrD1 of BRD4 over BrD2 of BRD4. ......by BioVision, Inc.,
MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2. ......by MedChemexpress Co., Ltd.
MS436 is a BRD4 inhibitor. MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM). MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. ......by MedKoo Biosciences, Inc.
MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. ......by Selleck Chemicals LLC
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. ......by Target Molecule Corp.
Potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Pink to red Solid EBNumber:EB000013526

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Epigenetics
Target Epigenetic Reader Domain
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MS436 - Not Found
MS436 - No Development Reported
7

Safety Data of MS436

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 5mg/USD176() USA
Apexbio Technology LLC 25mg/USD243(In stock) USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
BioVision, Inc., 5mg/USD115() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD104();10mg/USD136() USA
Cayman Chemical Company 5mg/USD95() USA
ChemieTek USA
Hello Bio Inc. 5mg/USD94() USA
Lancrix Chemicals. 50mg/USD495() China
MedChemexpress Co., Ltd. 5mg/USD104();10mg/USD136() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 5mg/USD220() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD104();10mg/USD136() China
Target Molecule Corp. 10mg/USD131();25mg/USD198();50mg/USD288() USA
Tocris Bioscience Inc. 10mg/USD199() USA
10

Related Products

Other Forms of 1395084-25-9

Name CAS No Formula MW

Recommended Compounds in Epigenetic Reader Domain

Name CAS No Formula MW
CPI-169 racemate 1450655-76-1 C27H36N4O5S 528.6635
RVX-208 1044870-39-4 C20H22N2O5 370.4
CPI-203 1446144-04-2 C19H18ClN5OS 399.9
JQ-1 (carboxylic acid) 202592-23-2 C19H17ClN4O2S 400.8819
GSK1324726A 1300031-52-0 C25H23ClN2O3 434.91
OTX-015 202590-98-5 C25H22ClN5O2S 491.99
UNC1999 1431612-23-5 C33H43N7O2 569.74
EPZ-6438 (trihydrochloride) 1403255-00-4 C34H47Cl3N4O4 682.12
EPZ-6438 1403254-99-8 C34H44N4O4 572.74
EI1 1418308-27-6 C23H26N4O2 390.48
GSK343 1346704-33-3 C31H39N7O2 541.69
EPZ005687 1396772-26-1 C32H37N5O3 539.67
GSK 525768A 1260530-25-3 C22H22ClN5O2 423.9
GSK126 1346574-57-9 C31H38N6O2 526.67
PFI-1 1403764-72-6 C16H17N3O4S 347.39
I-BET151 1300031-49-5 C23H21N5O3 415.44
GSK 525762A 1260907-17-2 C22H22ClN5O2 423.9
3-Deazaneplanocin A (hydrochloride) 120964-45-6 C12H15ClN4O3 298.73
(R)-(-)-JQ1 Enantiomer 1268524-71-5 C23H25ClN4O2S 456.9882
(+)-JQ-1 1268524-70-4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

MS436

Tags: buy 1395084-25-9 IC50 | 1395084-25-9 price | 1395084-25-9 cost | 1395084-25-9 solubility | 1395084-25-9 purchase | 1395084-25-9 manufacturer | 1395084-25-9 research buy | 1395084-25-9 order | 1395084-25-9 MSDS | 1395084-25-9 chemical structure | 1395084-25-9 Storage condition | 1395084-25-9 molecular weight | 1395084-25-9 mw | 1395084-25-9 datasheet | 1395084-25-9 supplier | 1395084-25-9 cell line | 1395084-25-9 NMR | 1395084-25-9 MS | 1395084-25-9 IR | 1395084-25-9 solubility | 1395084-25-9 Safe information | 1395084-25-9 Qc and Spectral Information | 1395084-25-9 Clinical Information | 1395084-25-9 Clinical Trial | 1395084-25-9 Route of Synthesis | 1395084-25-9 storage condition | 1395084-25-9 diseases and conditions | 1395084-25-9 flash point | 1395084-25-9 boiling point | 1395084-25-9 melting point | 1395084-25-9 storage condition | 1395084-25-9 brand