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1395084-25-9 (MS436)



MS436 MS436
Name MS436
Formula C18H17N5O3S
MW 383.42
CAS No. 1395084-25-9
Smiles O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3=NC=CC=C3)=O
Synonyms MS-436;MS 436; (E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide
InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+


MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. IC50 Value: 30-50 nM (Ki) [1] Target: BRD4 bromodomain MS436 exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference for the first bromodomain over the second.

Background Information

MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. ......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. ......by BOC Sciences
MS436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM for BrD1). It displays 10-fold selectivity for BrD1 of BRD4 over BrD2 of BRD4. ......by BioVision, Inc.,
MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2. ......by MedChemexpress Co., Ltd.
MS436 is a BRD4 inhibitor. MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM). MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. ......by MedKoo Biosciences, Inc.
MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. ......by Selleck Chemicals LLC
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. ......by Target Molecule Corp.
Potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:Pink to red Solid EBNumber:EB000013526

Storage condition


DMSO by MedChemexpress Co., Ltd.

Mechanism and Indication

Signaling Pathways Epigenetics
Target Epigenetic Reader Domain
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MS436 - Not Found
MS436 - No Development Reported

Safety Data of MS436


Spectral Information


Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 5mg/USD176() USA
Apexbio Technology LLC 25mg/USD243(In stock) USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
BioVision, Inc., 5mg/USD115() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD104();10mg/USD136() USA
Cayman Chemical Company 5mg/USD95() USA
ChemieTek USA
Hello Bio Inc. 5mg/USD94() USA
Lancrix Chemicals. 50mg/USD495() China
MedChemexpress Co., Ltd. 5mg/USD104();10mg/USD136() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 5mg/USD220() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD104();10mg/USD136() China
Target Molecule Corp. 10mg/USD131();25mg/USD198();50mg/USD288() USA
Tocris Bioscience Inc. 10mg/USD199() USA

Related Products

Other Forms of 1395084-25-9

Name CAS No Formula MW

Recommended Compounds in Epigenetic Reader Domain

Name CAS No Formula MW
CPI-169 racemate 1450655-76-1 C27H36N4O5S 528.6635
RVX-208 1044870-39-4 C20H22N2O5 370.4
CPI-203 1446144-04-2 C19H18ClN5OS 399.9
JQ-1 (carboxylic acid) 202592-23-2 C19H17ClN4O2S 400.8819
GSK1324726A 1300031-52-0 C25H23ClN2O3 434.91
OTX-015 202590-98-5 C25H22ClN5O2S 491.99
UNC1999 1431612-23-5 C33H43N7O2 569.74
EPZ-6438 (trihydrochloride) 1403255-00-4 C34H47Cl3N4O4 682.12
EPZ-6438 1403254-99-8 C34H44N4O4 572.74
EI1 1418308-27-6 C23H26N4O2 390.48
GSK343 1346704-33-3 C31H39N7O2 541.69
EPZ005687 1396772-26-1 C32H37N5O3 539.67
GSK 525768A 1260530-25-3 C22H22ClN5O2 423.9
GSK126 1346574-57-9 C31H38N6O2 526.67
PFI-1 1403764-72-6 C16H17N3O4S 347.39
I-BET151 1300031-49-5 C23H21N5O3 415.44
GSK 525762A 1260907-17-2 C22H22ClN5O2 423.9
3-Deazaneplanocin A (hydrochloride) 120964-45-6 C12H15ClN4O3 298.73
(R)-(-)-JQ1 Enantiomer 1268524-71-5 C23H25ClN4O2S 456.9882
(+)-JQ-1 1268524-70-4

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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