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|Synonyms||5-Methoxypsoralen; 4-Methoxy-7H-furo[3,2-g]chromen-7-one; 4-methoxy-7H-furo[3,2-g]chromen-7-one|
5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo; inhibit proliferation in the human hepatocellular carcinoma cell line. IC50 value: Target: anti cancer in vitro: 5-MOP increased the activity of NATand also increased the further metabolism of AAF at 24 h in the rat stomach.
|5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo; inhibit proliferation in the human hepatocellular carcinoma cell line. IC50 value: Target: anti cancer in vitro: 5-MOP increased the activity of NATand also increased the further metabolism of AAF at 24 h in the rat stomach. In the rat colon, no statistically significant changes caused by 5-MOP were observed in NAT activity, but 5-MOP increased the further metabolism of AAF at 24 to 72 h. 5-MOP decreased the activity of NAT only at 72-h incubation in SC-M1 cells. In COLO 205 cells, however, 5-MOP decreased the activity of NAT between 24 h and 72 h . 5-methoxypsoralen resulted in IL-8 inhibition at 10 microM concentration, without effects on cell proliferation. In synthesis, 5-methoxypsoralen can be taken into consideration to investigate mechanisms of neutrophil chemotactic signalling and for its potential application in modulating the excessive CF lung inflammation . High concentration of 5-MOP (5 x 10(-5) M) induced a time-dependent increase of tyrosinase activity and melanin content, which was correlated to an increase of both mRNA and protein levels of tyrosinase. These results demonstrate that the 5-MOP stimulation of melanogenesis is related to increased tyrosinase synthesis . Morphological analysis, cell viability assay, DNA analysis and cell-cycle analysis suggest that there are at least three modes of the suppressive effects shown by 5-MOP: (a) kills J5 cells directly; (b) induces apoptosis by arresting J5 cells at the G2/M phase in the cell cycle; (c) induces apoptosis through an independent pathway with cell-cycle arrest at 24-72 h of exposure . in vivo: In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivity. However, mean minimum phototoxic doses (MPD) were 30 to 50% greater with 5-methoxypsoralen than with 8-methoxypsoralen within individuals; this suggests lower photoactivity with 5-methoxypsoralen . ......by MedChemexpress Co., Ltd.|
|Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. ......by Target Molecule Corp.|
|Appearance:White to off-white Solid||EBNumber:EB000013521|
|DMSO||by MedChemexpress Co., Ltd.|
|Company||Price and Availability||Country/Region|
|Andard-Mount Company Limited||UNITED KINGDOM|
|Baoji Herbest Bio-Tech Co., Ltd.||China|
|MedChemexpress Co., Ltd.||1g/USD120(In stock);5g/USD480(In stock)||USA|
|Selleck Chemicals LLC||USA|
|Shanghai Haoyuan Chemexpress Co., Ltd.||1g/USD120(In stock);5g/USD480(In stock)||China|
|Target Molecule Corp.||10mg/USD89();25mg/USD146();50mg/USD209()||USA|
|Berberine (chloride hydrate)||141433-60-5||C20H18ClNO4||371.81|
|H 89 (hydrochloride)||130964-39-5||C20H22BrCl2N3O2S||519.28|
|Ruxolitinib (S enantiomer)||941685-37-6||C17H18N6||306.37|
. Lee YM, et al. Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines. In Vivo. 2005 Nov-Dec;19(6):1061-9.